Expansion of ventral foregut is linked to changes in the enhancer landscape for organ-specific differentiation

Research output: Contribution to journal › Journal article › Research › peer-review

Standard

Expansion of ventral foregut is linked to changes in the enhancer landscape for organ-specific differentiation. / Wong, Yan Fung; Kumar, Yatendra; Proks, Martin; Herrera, Jose Alejandro Romero; Rothová, Michaela Mrugala; Monteiro, Rita S.; Pozzi, Sara; Jennings, Rachel E.; Hanley, Neil A.; Bickmore, Wendy A.; Brickman, Joshua M.

In: Nature Cell Biology, Vol. 25, 2023, p. 481-492.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Wong, YF, Kumar, Y, Proks, M, Herrera, JAR, Rothová, MM, Monteiro, RS, Pozzi, S, Jennings, RE, Hanley, NA, Bickmore, WA & Brickman, JM 2023, 'Expansion of ventral foregut is linked to changes in the enhancer landscape for organ-specific differentiation', Nature Cell Biology, vol. 25, pp. 481-492. https://doi.org/10.1038/s41556-022-01075-8

APA

Wong, Y. F., Kumar, Y., Proks, M., Herrera, J. A. R., Rothová, M. M., Monteiro, R. S., Pozzi, S., Jennings, R. E., Hanley, N. A., Bickmore, W. A., & Brickman, J. M. (2023). Expansion of ventral foregut is linked to changes in the enhancer landscape for organ-specific differentiation. Nature Cell Biology, 25, 481-492. https://doi.org/10.1038/s41556-022-01075-8

Vancouver

Wong YF, Kumar Y, Proks M, Herrera JAR, Rothová MM, Monteiro RS et al. Expansion of ventral foregut is linked to changes in the enhancer landscape for organ-specific differentiation. Nature Cell Biology. 2023;25:481-492. https://doi.org/10.1038/s41556-022-01075-8

Author

Wong, Yan Fung ; Kumar, Yatendra ; Proks, Martin ; Herrera, Jose Alejandro Romero ; Rothová, Michaela Mrugala ; Monteiro, Rita S. ; Pozzi, Sara ; Jennings, Rachel E. ; Hanley, Neil A. ; Bickmore, Wendy A. ; Brickman, Joshua M. / Expansion of ventral foregut is linked to changes in the enhancer landscape for organ-specific differentiation. In: Nature Cell Biology. 2023 ; Vol. 25. pp. 481-492.

Bibtex

@article{8c1f841358aa433aa03727f2b2fafabf,
title = "Expansion of ventral foregut is linked to changes in the enhancer landscape for organ-specific differentiation",
abstract = "Cell proliferation is fundamental for almost all stages of development and differentiation that require an increase in cell number. Although cell cycle phase has been associated with differentiation, the actual process of proliferation has not been considered as having a specific role. Here we exploit human embryonic stem cell-derived endodermal progenitors that we find are an in vitro model for the ventral foregut. These cells exhibit expansion-dependent increases in differentiation efficiency to pancreatic progenitors that are linked to organ-specific enhancer priming at the level of chromatin accessibility and the decommissioning of lineage-inappropriate enhancers. Our findings suggest that cell proliferation in embryonic development is about more than tissue expansion; it is required to ensure equilibration of gene regulatory networks allowing cells to become primed for future differentiation. Expansion of lineage-specific intermediates may therefore be an important step in achieving high-fidelity in vitro differentiation.",
author = "Wong, {Yan Fung} and Yatendra Kumar and Martin Proks and Herrera, {Jose Alejandro Romero} and Rothov{\'a}, {Michaela Mrugala} and Monteiro, {Rita S.} and Sara Pozzi and Jennings, {Rachel E.} and Hanley, {Neil A.} and Bickmore, {Wendy A.} and Brickman, {Joshua M.}",
note = "Publisher Copyright: {\textcopyright} 2023, The Author(s).",
year = "2023",
doi = "10.1038/s41556-022-01075-8",
language = "English",
volume = "25",
pages = "481--492",
journal = "Nature Cell Biology",
issn = "1465-7392",
publisher = "nature publishing group",

}

RIS

TY - JOUR

T1 - Expansion of ventral foregut is linked to changes in the enhancer landscape for organ-specific differentiation

AU - Wong, Yan Fung

AU - Kumar, Yatendra

AU - Proks, Martin

AU - Herrera, Jose Alejandro Romero

AU - Rothová, Michaela Mrugala

AU - Monteiro, Rita S.

AU - Pozzi, Sara

AU - Jennings, Rachel E.

AU - Hanley, Neil A.

AU - Bickmore, Wendy A.

AU - Brickman, Joshua M.

N1 - Publisher Copyright: © 2023, The Author(s).

PY - 2023

Y1 - 2023

N2 - Cell proliferation is fundamental for almost all stages of development and differentiation that require an increase in cell number. Although cell cycle phase has been associated with differentiation, the actual process of proliferation has not been considered as having a specific role. Here we exploit human embryonic stem cell-derived endodermal progenitors that we find are an in vitro model for the ventral foregut. These cells exhibit expansion-dependent increases in differentiation efficiency to pancreatic progenitors that are linked to organ-specific enhancer priming at the level of chromatin accessibility and the decommissioning of lineage-inappropriate enhancers. Our findings suggest that cell proliferation in embryonic development is about more than tissue expansion; it is required to ensure equilibration of gene regulatory networks allowing cells to become primed for future differentiation. Expansion of lineage-specific intermediates may therefore be an important step in achieving high-fidelity in vitro differentiation.

AB - Cell proliferation is fundamental for almost all stages of development and differentiation that require an increase in cell number. Although cell cycle phase has been associated with differentiation, the actual process of proliferation has not been considered as having a specific role. Here we exploit human embryonic stem cell-derived endodermal progenitors that we find are an in vitro model for the ventral foregut. These cells exhibit expansion-dependent increases in differentiation efficiency to pancreatic progenitors that are linked to organ-specific enhancer priming at the level of chromatin accessibility and the decommissioning of lineage-inappropriate enhancers. Our findings suggest that cell proliferation in embryonic development is about more than tissue expansion; it is required to ensure equilibration of gene regulatory networks allowing cells to become primed for future differentiation. Expansion of lineage-specific intermediates may therefore be an important step in achieving high-fidelity in vitro differentiation.

U2 - 10.1038/s41556-022-01075-8

DO - 10.1038/s41556-022-01075-8

M3 - Journal article

C2 - 36690849

AN - SCOPUS:85146688991

VL - 25

SP - 481

EP - 492

JO - Nature Cell Biology

JF - Nature Cell Biology

SN - 1465-7392

ER -

ID: 335965401