Serup Group - Developmental Biology of the Pancreas


The Serup lab investigates how cell-cell signalling interfaces with lineage-specific transcription factors to regulate cell fate decisions. The major focus of the lab is to understand how Notch signalling controls progenitor behaviour and differentiation in the developing pancreas.

The group is particularly interested in understanding how Notch signalling regulates several distinct processes during pancreatic development. They unravel how gene regulatory network architecture ensures robust cell fate regulation and how ultradian oscillations in gene activity are linked to cell proliferation and fate choice. They explore the generality of their findings in other organ systems.

Most of their studies are done with mice and human pluripotent stem cells, using a wide variety of techniques including gene targeting, transgenic mice, tissue explants, NGS-based assays, immunohistochemistry, confocal microscopy, and time-lapse imaging.

The aim of all these experiments is to understand the genetic and cellular interactions that direct pancreatic development in vivo and in vitro during differentiation of human pluripotent stem cells.



  • To determine whether and how different Notch ligands regulate different processes in pancreas development and whether redundancy exist between different ligands.

  • To elucidate the gene regulatory network architecture downstream of Notch signalling in order to understand how it ensures robust regulation of cell fate in pancreatic development.

  • To determine how tissue geometry and Notch signalling interact to ensure proximodistal patterning of the pancreas.

  • To develop improved protocols for directed differentiation of human pluripotent stem cells towards insulin-producing β-cells for use in cell-based diabetes therapy.

  • To develop novel computational tools that will facilitate understanding of the above-mentioned processes.



List of publications by Palle Serup



  • Ryoichiro Kageyama, RIKEN Center for Brain Science, Hirosawa Wako City, Japan
  • Jorge Ferrer, Center for Genomic Regulation, Barcelona, Spain.
  • Gerard Gradwohl, IGBMC, Strasbourg, France.
  • Meritxell Huch, MPI-CBG, Dresden, Germany.
  • Danwei Huangfu, MSKCC, New York, USA.
  • Josh Brickman, NNF Center for Stem Cell Medicine, Copenhagen, Denmark.
  • Kim B. Jensen, NNF Center for Stem Cell Medicine, Copenhagen, Denmark.
  • Agnete Kirkeby, NNF Center for Stem Cell Medicine, Copenhagen, Denmark.



  • Novo Nordisk Foundation Nordic Endocrinology 2020 - 2024 for the project: ''Decoding Notch signaling - The importance of cycling at the right pace''
  • Novo Nordisk Foundation Center for Stem Cell Medicine (NNF21CC0073729)


Staff List - Serup Group

Name Title Job responsibilities Phone E-mail
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Jørgensen, Mette Christine Staff Scientist Staff Scientist   E-mail
Mjøseng, Heidi Katharina Academic Research Staff +4535333829 E-mail
Nissen, Silas Boye International Researcher Postdoc   E-mail
Pajuelo Reyes, Cecilia Isabel PhD Fellow +4535325826 E-mail
Quaranta, Roberto Assistant Professor   E-mail
Raineri, Silvia Postdoc   E-mail
Seymour, Philip Allan Assistant Professor   E-mail
Vidal I Pitarch, Berta Academic Research Staff   E-mail
Xu, Xiaochan Assistant Professor Postdoc +4535326306 E-mail