Serup Group - Developmental Biology of the Pancreas
The Serup group investigates how cell-cell signaling interfaces with lineage-specific transcription factors to regulate cell fate decisions. The group main focus is on how Notch signaling controls progenitor behaviour and differentiation in the developing pancreas.
The group is particularly interested in understanding how Notch signalling regulates several distinct processes during pancreatic development. The majority of their studies are done with chicken, mice, and embryonic stem cells, using a wide variety of techniques including gene targeting, transgenic mice, gene arrays, immunohistochemistry, confocal microscopy, tissue explants, and in ovo electroporation. The aim of all these experiments is to understand the genetic and cellular interactions that direct pancreatic
The group is currently mapping the temporal requirement of Notch signalling in different processes occurring during pancreatic development as well as determining the cell biological details of Notch signalling events. They are also involved in a collaborative tool-generating project that aims to develop new fluorescent reporters for a number of developmental signalling pathways. These tools will significantly improve our ability to study signalling events in vivo and in vitro.
Jorgensen, M.C., de Lichtenberg, K.H., Collin, C.A., Klinck, R., Ekberg, J.H., Engelstoft, M.S., Lickert, H., and Serup, P. (2018). Neurog3-dependent pancreas dysgenesis causes ectopic pancreas in Hes1 mutant mice. Development 145, doi:10.1242/dev.163568.
Seymour, P.A., Collin, C.A., Jorgensen, M.C., Imayoshi, I., Kageyama, R., and Serup, P. (2018). Dll1 and Jag1 are differentially required to specify proximal and distal pancreatic duct compartments. bioRxiv 336529, doi: 10.1101/336529
de Lichtenberg, K.H., Funa, N.S., Nakic, N., Ferrer, J., Zhu, Z., Huangfu, D., and Serup, P. (2018). Genome- wide identification of HES1 target genes uncover novel roles for HES1 in pancreatic development. bioRxiv 335869, doi: 10.1101/335869
Horn, S., Kobberup, S., Jorgensen, M.C., Kalisz, M., Klein, T., Kageyama, R., Gegg, M., Lickert, H., Lindner, J., Magnuson, M.A., Kong, Y.Y., Serup, P., Ahnfelt-Ronne, J., and Jensen, J.N. (2012). Mind bomb 1 is required for pancreatic beta-cell formation. Proceedings of the National Academy of Sciences USA 109, 7356-7361, doi:10.1073/pnas.1203605109.
Ahnfelt-Rønne, J., Jørgensen, M.C., Klinck, R., Jensen, J.N., Füchtbauer, E., Deering, T., MacDonald, R.J., Wright, C.V.E., Madsen, O.D., and Serup, P. (2012). Ptf1a-mediated control of Dll1 reveals an alternative to the lateral inhibition mechanism. Development 139, 39-45, doi: 10.1242/dev.071761.
Kalisz, M., Winzi, M., Bisgaard, H.C., and Serup, P., (2012). EVEN-SKIPPED HOMEOBOX 1 controls human ES cell differentiation by directly repressing GOOSECOID expression. Developmental Biology, 362(1), 94-103, doi:10.1016/j.ydbio.2011.11.017.
Serup, P., Gustavsen, C., Klein, T., Potter, L.A., Lin, R., Mullapudi, N., Wandzioch, E., Hines, A., Davis, A., Bruun, C., Engberg, N., Petersen, D.R., Peterslund, J.M., Macdonald, R.J., Grapin-Botton, A., Magnuson, M.A. and Zaret, K.S. (2012). Partial promoter substitutions generating transcriptional sentinels of diverse signaling pathways in embryonic stem cells and mice. Disease Models and Mechanisms 5, 956-966, doi:10.1242/dmm.009696.
Petersen, D.R., Gustavsen, C., Lindskog, S.R., Magnuson, M.A., Zaret, K.S., and Serup, P. (2012). Engineering Artificial Signalling Centres to Polarize Embryoid Body Differentiation. Stem Cells and Development 21, 647-653, doi: 10.1089/scd.2011.0344
Research Profile
Palle Serup and his research group have during recent years focused on the role of cell to cell signalling in the control of pancreatic endocrine development and on the role of key transcription factors in the regulation of beta cell specification. Also, he has, as the principal investigator of both EU and NIH sponsored projects, together with teams of European and American scientists been instrumental in expanding our knowledge of intercellular signalling events and cell-autonomous transcription factors in pancreatic development. Palle Serup is a Research Collaborator of the Danish Diabetes Academy and has authored more than 100 scientific papers including 85 peer-reviewed original papers. His h-index is 46.
Awards and Honours
Palle Serup has received a postdoctoral fellowship from The Clayton Foundation for Research, Austin, Texas in 1990. For his contributions as grant reviewer Palle Serup has received the Mary Jane Kugel Award from the Juvenile Diabetes Research Foundation (JDRF). He has served on the Medical Science Review Committee of the JDRF since 2001, and from 2007 to 2010 as Chairman of the committee for Innovation grants.
In 2010 Palle Serup was appointed Adjunct Professor in Developmental Biology of pancreas and islet cell differentiation at University of Southern Denmark.
Key Recent Discoveries
Jorgensen, M.C., de Lichtenberg, K.H., Collin, C.A., Klinck, R., Ekberg, J.H., Engelstoft, M.S., Lickert, H., and Serup, P. (2018). Neurog3-dependent pancreas dysgenesis causes ectopic pancreas in Hes1 mutant mice. Development 145, doi:10.1242/dev.163568.
Seymour, P.A., Collin, C.A., Jorgensen, M.C., Imayoshi, I., Kageyama, R., and Serup, P. (2018). Dll1 and Jag1 are differentially required to specify proximal and distal pancreatic duct compartments. bioRxiv 336529, doi: 10.1101/336529
de Lichtenberg, K.H., Funa, N.S., Nakic, N., Ferrer, J., Zhu, Z., Huangfu, D., and Serup, P. (2018). Genome- wide identification of HES1 target genes uncover novel roles for HES1 in pancreatic development. bioRxiv 335869, doi: 10.1101/335869
Horn, S., Kobberup, S., Jorgensen, M.C., Kalisz, M., Klein, T., Kageyama, R., Gegg, M., Lickert, H., Lindner, J., Magnuson, M.A., Kong, Y.Y., Serup, P., Ahnfelt-Ronne, J., and Jensen, J.N. (2012). Mind bomb 1 is required for pancreatic beta-cell formation. Proceedings of the National Academy of Sciences USA 109, 7356-7361, doi:10.1073/pnas.1203605109.
Ahnfelt-Rønne, J., Jørgensen, M.C., Klinck, R., Jensen, J.N., Füchtbauer, E., Deering, T., MacDonald, R.J., Wright, C.V.E., Madsen, O.D., and Serup, P. (2012). Ptf1a-mediated control of Dll1 reveals an alternative to the lateral inhibition mechanism. Development 139, 39-45, doi: 10.1242/dev.071761.
Kalisz, M., Winzi, M., Bisgaard, H.C., and Serup, P., (2012). EVEN-SKIPPED HOMEOBOX 1 controls human ES cell differentiation by directly repressing GOOSECOID expression. Developmental Biology, 362(1), 94-103, doi:10.1016/j.ydbio.2011.11.017.
Serup, P., Gustavsen, C., Klein, T., Potter, L.A., Lin, R., Mullapudi, N., Wandzioch, E., Hines, A., Davis, A., Bruun, C., Engberg, N., Petersen, D.R., Peterslund, J.M., Macdonald, R.J., Grapin-Botton, A., Magnuson, M.A. and Zaret, K.S. (2012). Partial promoter substitutions generating transcriptional sentinels of diverse signaling pathways in embryonic stem cells and mice. Disease Models and Mechanisms 5, 956-966, doi:10.1242/dmm.009696.
Petersen, D.R., Gustavsen, C., Lindskog, S.R., Magnuson, M.A., Zaret, K.S., and Serup, P. (2012). Engineering Artificial Signalling Centres to Polarize Embryoid Body Differentiation. Stem Cells and Development 21, 647-653, doi: 10.1089/scd.2011.0344
Palle Serup: Talking Cells
Staff List - Serup Group
| Name | Title | Job responsibilities | Phone | |
|---|---|---|---|---|
| Search in Name | Search in Title | Search in Job responsibilities | Search in Phone | |
| Esen, Deniz | PhD Fellow | +4535321464 | ||
| Jørgensen, Mette Christine | Staff Scientist | Staff Scientist | ||
| Mjøseng, Heidi Katharina | PhD Fellow | +4535333829 | ||
| Nissen, Silas Boye | International Researcher | Postdoc | ||
| Quaranta, Roberto | Assistant Professor | |||
| Raineri, Silvia | Postdoc | Postdoc | ||
| Serup, Palle | Professor | Professor, Group Leader | +4540220026 | |
| Seymour, Philip Allan | Assistant Professor | |||
| Xu, Xiaochan | Postdoc | Postdoc | +4535326306 |
