What can we learn from kidney organoids?
Research output: Contribution to journal › Review › Research › peer-review
The ability to generate 3-dimensional models of the developing human kidney via the directed differentiation of pluripotent stem cells—termed kidney organoids—has been hailed as a major advance in experimental nephrology. Although these provide an opportunity to interrogate human development, model-specific kidney diseases facilitate drug screening and even deliver bioengineered tissue; most of these prophetic end points remain to be realized. Indeed, at present we are still finding out what we can learn and what we cannot learn from this approach. In this review, we will summarize the approaches available to generate models of the human kidney from stem cells, the existing successful applications of kidney organoids, their limitations, and remaining challenges.
Original language | English |
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Journal | Kidney International |
Volume | 102 |
Issue number | 5 |
Pages (from-to) | 1013-1029 |
Number of pages | 17 |
ISSN | 0085-2538 |
DOIs | |
Publication status | Published - 2022 |
Bibliographical note
Publisher Copyright:
© 2022 International Society of Nephrology
- bioengineering, disease modeling, iPSC, kidney organoids, stem cell
Research areas
ID: 342615272