What can we learn from kidney organoids?

Research output: Contribution to journal › Review › Research › peer-review

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What can we learn from kidney organoids? / Dorison, Aude; Forbes, Thomas A.; Little, Melissa H.

In: Kidney International, Vol. 102, No. 5, 2022, p. 1013-1029.

Research output: Contribution to journal › Review › Research › peer-review

Harvard

Dorison, A, Forbes, TA & Little, MH 2022, 'What can we learn from kidney organoids?', Kidney International, vol. 102, no. 5, pp. 1013-1029. https://doi.org/10.1016/j.kint.2022.06.032

APA

Dorison, A., Forbes, T. A., & Little, M. H. (2022). What can we learn from kidney organoids? Kidney International, 102(5), 1013-1029. https://doi.org/10.1016/j.kint.2022.06.032

Vancouver

Dorison A, Forbes TA, Little MH. What can we learn from kidney organoids? Kidney International. 2022;102(5):1013-1029. https://doi.org/10.1016/j.kint.2022.06.032

Author

Dorison, Aude ; Forbes, Thomas A. ; Little, Melissa H. / What can we learn from kidney organoids?. In: Kidney International. 2022 ; Vol. 102, No. 5. pp. 1013-1029.

Bibtex

@article{7d8e039cee344482b8c733752339b313,
title = "What can we learn from kidney organoids?",
abstract = "The ability to generate 3-dimensional models of the developing human kidney via the directed differentiation of pluripotent stem cells—termed kidney organoids—has been hailed as a major advance in experimental nephrology. Although these provide an opportunity to interrogate human development, model-specific kidney diseases facilitate drug screening and even deliver bioengineered tissue; most of these prophetic end points remain to be realized. Indeed, at present we are still finding out what we can learn and what we cannot learn from this approach. In this review, we will summarize the approaches available to generate models of the human kidney from stem cells, the existing successful applications of kidney organoids, their limitations, and remaining challenges.",
keywords = "bioengineering, disease modeling, iPSC, kidney organoids, stem cell",
author = "Aude Dorison and Forbes, {Thomas A.} and Little, {Melissa H.}",
note = "Publisher Copyright: {\textcopyright} 2022 International Society of Nephrology",
year = "2022",
doi = "10.1016/j.kint.2022.06.032",
language = "English",
volume = "102",
pages = "1013--1029",
journal = "Kidney International",
issn = "0085-2538",
publisher = "Elsevier",
number = "5",

}

RIS

TY - JOUR

T1 - What can we learn from kidney organoids?

AU - Dorison, Aude

AU - Forbes, Thomas A.

AU - Little, Melissa H.

N1 - Publisher Copyright: © 2022 International Society of Nephrology

PY - 2022

Y1 - 2022

N2 - The ability to generate 3-dimensional models of the developing human kidney via the directed differentiation of pluripotent stem cells—termed kidney organoids—has been hailed as a major advance in experimental nephrology. Although these provide an opportunity to interrogate human development, model-specific kidney diseases facilitate drug screening and even deliver bioengineered tissue; most of these prophetic end points remain to be realized. Indeed, at present we are still finding out what we can learn and what we cannot learn from this approach. In this review, we will summarize the approaches available to generate models of the human kidney from stem cells, the existing successful applications of kidney organoids, their limitations, and remaining challenges.

AB - The ability to generate 3-dimensional models of the developing human kidney via the directed differentiation of pluripotent stem cells—termed kidney organoids—has been hailed as a major advance in experimental nephrology. Although these provide an opportunity to interrogate human development, model-specific kidney diseases facilitate drug screening and even deliver bioengineered tissue; most of these prophetic end points remain to be realized. Indeed, at present we are still finding out what we can learn and what we cannot learn from this approach. In this review, we will summarize the approaches available to generate models of the human kidney from stem cells, the existing successful applications of kidney organoids, their limitations, and remaining challenges.

KW - bioengineering

KW - disease modeling

KW - iPSC

KW - kidney organoids

KW - stem cell

U2 - 10.1016/j.kint.2022.06.032

DO - 10.1016/j.kint.2022.06.032

M3 - Review

C2 - 35970244

AN - SCOPUS:85138175294

VL - 102

SP - 1013

EP - 1029

JO - Kidney International

JF - Kidney International

SN - 0085-2538

IS - 5

ER -

ID: 342615272