Gene expression profiles during beta cell maturation and after IL-1beta exposure reveal important roles of Pdx-1 and Nkx6.1 for IL-1beta sensitivity
Research output: Contribution to journal › Journal article › Research › peer-review
Maturation of the beta cells in the islets of Langerhans is dependent upon sequential activation of different transcription factors such as Pdx-1 and Nkx6.1. This maturation is associated with an acquired sensitivity to cytokines and may eventually lead to type 1 diabetes. The aims of this study were to characterise changes in mRNA expression during beta cell maturation as well as after interleukin-1beta (IL-1beta) exposure.
| Original language | English |
|---|---|
| Journal | Diabetologia |
| Volume | 47 |
| Issue number | 12 |
| Pages (from-to) | 2185-99 |
| Number of pages | 15 |
| ISSN | 0012-186X |
| DOIs | |
| Publication status | Published - Dec 2004 |
| Externally published | Yes |
- Animals, Base Sequence, Cell Line, DNA Primers, Gene Expression Profiling, Gene Expression Regulation, Homeodomain Proteins, Interleukin-1, Islets of Langerhans, Islets of Langerhans Transplantation, RNA, Complementary, RNA, Messenger, Rats, Trans-Activators, Transcription, Genetic
Research areas
ID: 46485091