The epidermis comprises autonomous compartments maintained by distinct stem cell populations

Research output: Contribution to journal › Journal article › Research

Standard

The epidermis comprises autonomous compartments maintained by distinct stem cell populations. / Page, Mahalia E; Lombard, Patrick; Ng, Felicia; Göttgens, Berthold; Jensen, Kim B.

In: Cell Stem Cell, Vol. 13, No. 4, 03.10.2013, p. 471-82.

Research output: Contribution to journal › Journal article › Research

Harvard

Page, ME, Lombard, P, Ng, F, Göttgens, B & Jensen, KB 2013, 'The epidermis comprises autonomous compartments maintained by distinct stem cell populations', Cell Stem Cell, vol. 13, no. 4, pp. 471-82. https://doi.org/10.1016/j.stem.2013.07.010

APA

Page, M. E., Lombard, P., Ng, F., Göttgens, B., & Jensen, K. B. (2013). The epidermis comprises autonomous compartments maintained by distinct stem cell populations. Cell Stem Cell, 13(4), 471-82. https://doi.org/10.1016/j.stem.2013.07.010

Vancouver

Page ME, Lombard P, Ng F, Göttgens B, Jensen KB. The epidermis comprises autonomous compartments maintained by distinct stem cell populations. Cell Stem Cell. 2013 Oct 3;13(4):471-82. https://doi.org/10.1016/j.stem.2013.07.010

Author

Page, Mahalia E ; Lombard, Patrick ; Ng, Felicia ; Göttgens, Berthold ; Jensen, Kim B. / The epidermis comprises autonomous compartments maintained by distinct stem cell populations. In: Cell Stem Cell. 2013 ; Vol. 13, No. 4. pp. 471-82.

Bibtex

@article{9947fad599634f5b833b4341b30c5b26,
title = "The epidermis comprises autonomous compartments maintained by distinct stem cell populations",
abstract = "The complex anatomy of the epidermis contains multiple adult stem cell populations, but the extent to which they functionally overlap during homeostasis, wound healing, and tumor initiation remains poorly defined. Here, we demonstrate that Lrig1(+ve) cells are highly proliferative epidermal stem cells. Long-term clonal analysis reveals that Lrig1(+ve) cells maintain the upper pilosebaceous unit, containing the infundibulum and sebaceous gland as independent compartments, but contribute to neither the hair follicle nor the interfollicular epidermis, which are maintained by distinct stem cell populations. In contrast, upon wounding, stem cell progeny from multiple compartments acquire lineage plasticity and make permanent contributions to regenerating tissue. We further show that oncogene activation in Lrig1(+ve) cells drives hyperplasia but requires auxiliary stimuli for tumor formation. In summary, our data demonstrate that epidermal stem cells are lineage restricted during homeostasis and suggest that compartmentalization may constitute a conserved mechanism underlying epithelial tissue maintenance.",
author = "Page, {Mahalia E} and Patrick Lombard and Felicia Ng and Berthold G{\"o}ttgens and Jensen, {Kim B}",
note = "Copyright {\textcopyright} 2013 The Authors. Published by Elsevier Inc. All rights reserved.",
year = "2013",
month = oct,
day = "3",
doi = "10.1016/j.stem.2013.07.010",
language = "English",
volume = "13",
pages = "471--82",
journal = "Cell Stem Cell",
issn = "1934-5909",
publisher = "Cell Press",
number = "4",

}

RIS

TY - JOUR

T1 - The epidermis comprises autonomous compartments maintained by distinct stem cell populations

AU - Page, Mahalia E

AU - Lombard, Patrick

AU - Ng, Felicia

AU - Göttgens, Berthold

AU - Jensen, Kim B

N1 - Copyright © 2013 The Authors. Published by Elsevier Inc. All rights reserved.

PY - 2013/10/3

Y1 - 2013/10/3

N2 - The complex anatomy of the epidermis contains multiple adult stem cell populations, but the extent to which they functionally overlap during homeostasis, wound healing, and tumor initiation remains poorly defined. Here, we demonstrate that Lrig1(+ve) cells are highly proliferative epidermal stem cells. Long-term clonal analysis reveals that Lrig1(+ve) cells maintain the upper pilosebaceous unit, containing the infundibulum and sebaceous gland as independent compartments, but contribute to neither the hair follicle nor the interfollicular epidermis, which are maintained by distinct stem cell populations. In contrast, upon wounding, stem cell progeny from multiple compartments acquire lineage plasticity and make permanent contributions to regenerating tissue. We further show that oncogene activation in Lrig1(+ve) cells drives hyperplasia but requires auxiliary stimuli for tumor formation. In summary, our data demonstrate that epidermal stem cells are lineage restricted during homeostasis and suggest that compartmentalization may constitute a conserved mechanism underlying epithelial tissue maintenance.

AB - The complex anatomy of the epidermis contains multiple adult stem cell populations, but the extent to which they functionally overlap during homeostasis, wound healing, and tumor initiation remains poorly defined. Here, we demonstrate that Lrig1(+ve) cells are highly proliferative epidermal stem cells. Long-term clonal analysis reveals that Lrig1(+ve) cells maintain the upper pilosebaceous unit, containing the infundibulum and sebaceous gland as independent compartments, but contribute to neither the hair follicle nor the interfollicular epidermis, which are maintained by distinct stem cell populations. In contrast, upon wounding, stem cell progeny from multiple compartments acquire lineage plasticity and make permanent contributions to regenerating tissue. We further show that oncogene activation in Lrig1(+ve) cells drives hyperplasia but requires auxiliary stimuli for tumor formation. In summary, our data demonstrate that epidermal stem cells are lineage restricted during homeostasis and suggest that compartmentalization may constitute a conserved mechanism underlying epithelial tissue maintenance.

U2 - 10.1016/j.stem.2013.07.010

DO - 10.1016/j.stem.2013.07.010

M3 - Journal article

C2 - 23954751

VL - 13

SP - 471

EP - 482

JO - Cell Stem Cell

JF - Cell Stem Cell

SN - 1934-5909

IS - 4

ER -

ID: 94413643