Single-cell transcriptomics of human traumatic brain injury reveals activation of endogenous retroviruses in oligodendroglia

Research output: Contribution to journal › Journal article › Research › peer-review

Standard

Single-cell transcriptomics of human traumatic brain injury reveals activation of endogenous retroviruses in oligodendroglia. / Garza, Raquel; Sharma, Yogita; Atacho, Diahann A.M.; Thiruvalluvan, Arun; Abu Hamdeh, Sami; Jönsson, Marie E.; Horvath, Vivien; Adami, Anita; Ingelsson, Martin; Jern, Patric; Hammell, Molly Gale; Englund, Elisabet; Kirkeby, Agnete; Jakobsson, Johan; Marklund, Niklas.

In: Cell Reports, Vol. 42, No. 11, 113395, 2023.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Garza, R, Sharma, Y, Atacho, DAM, Thiruvalluvan, A, Abu Hamdeh, S, Jönsson, ME, Horvath, V, Adami, A, Ingelsson, M, Jern, P, Hammell, MG, Englund, E, Kirkeby, A, Jakobsson, J & Marklund, N 2023, 'Single-cell transcriptomics of human traumatic brain injury reveals activation of endogenous retroviruses in oligodendroglia', Cell Reports, vol. 42, no. 11, 113395. https://doi.org/10.1016/j.celrep.2023.113395

APA

Garza, R., Sharma, Y., Atacho, D. A. M., Thiruvalluvan, A., Abu Hamdeh, S., Jönsson, M. E., Horvath, V., Adami, A., Ingelsson, M., Jern, P., Hammell, M. G., Englund, E., Kirkeby, A., Jakobsson, J., & Marklund, N. (2023). Single-cell transcriptomics of human traumatic brain injury reveals activation of endogenous retroviruses in oligodendroglia. Cell Reports, 42(11), [113395]. https://doi.org/10.1016/j.celrep.2023.113395

Vancouver

Garza R, Sharma Y, Atacho DAM, Thiruvalluvan A, Abu Hamdeh S, Jönsson ME et al. Single-cell transcriptomics of human traumatic brain injury reveals activation of endogenous retroviruses in oligodendroglia. Cell Reports. 2023;42(11). 113395. https://doi.org/10.1016/j.celrep.2023.113395

Author

Garza, Raquel ; Sharma, Yogita ; Atacho, Diahann A.M. ; Thiruvalluvan, Arun ; Abu Hamdeh, Sami ; Jönsson, Marie E. ; Horvath, Vivien ; Adami, Anita ; Ingelsson, Martin ; Jern, Patric ; Hammell, Molly Gale ; Englund, Elisabet ; Kirkeby, Agnete ; Jakobsson, Johan ; Marklund, Niklas. / Single-cell transcriptomics of human traumatic brain injury reveals activation of endogenous retroviruses in oligodendroglia. In: Cell Reports. 2023 ; Vol. 42, No. 11.

Bibtex

@article{c153f824b323482db769f178ea3f5f74,
title = "Single-cell transcriptomics of human traumatic brain injury reveals activation of endogenous retroviruses in oligodendroglia",
abstract = "Traumatic brain injury (TBI) is a leading cause of chronic brain impairment and results in a robust, but poorly understood, neuroinflammatory response that contributes to the long-term pathology. We used single-nuclei RNA sequencing (snRNA-seq) to study transcriptomic changes in different cell populations in human brain tissue obtained acutely after severe, life-threatening TBI. This revealed a unique transcriptional response in oligodendrocyte precursors and mature oligodendrocytes, including the activation of a robust innate immune response, indicating an important role for oligodendroglia in the initiation of neuroinflammation. The activation of an innate immune response correlated with transcriptional upregulation of endogenous retroviruses in oligodendroglia. This observation was causally linked in vitro using human glial progenitors, implicating these ancient viral sequences in human neuroinflammation. In summary, this work provides insight into the initiating events of the neuroinflammatory response in TBI, which has therapeutic implications.",
keywords = "CP: Neuroscience, endogenous retroviruses, interferon response, neuroinflammation, oligodendroglia, traumatic brain injury",
author = "Raquel Garza and Yogita Sharma and Atacho, {Diahann A.M.} and Arun Thiruvalluvan and {Abu Hamdeh}, Sami and J{\"o}nsson, {Marie E.} and Vivien Horvath and Anita Adami and Martin Ingelsson and Patric Jern and Hammell, {Molly Gale} and Elisabet Englund and Agnete Kirkeby and Johan Jakobsson and Niklas Marklund",
note = "Publisher Copyright: {\textcopyright} 2023 The Author(s)",
year = "2023",
doi = "10.1016/j.celrep.2023.113395",
language = "English",
volume = "42",
journal = "Cell Reports",
issn = "2211-1247",
publisher = "Cell Press",
number = "11",

}

RIS

TY - JOUR

T1 - Single-cell transcriptomics of human traumatic brain injury reveals activation of endogenous retroviruses in oligodendroglia

AU - Garza, Raquel

AU - Sharma, Yogita

AU - Atacho, Diahann A.M.

AU - Thiruvalluvan, Arun

AU - Abu Hamdeh, Sami

AU - Jönsson, Marie E.

AU - Horvath, Vivien

AU - Adami, Anita

AU - Ingelsson, Martin

AU - Jern, Patric

AU - Hammell, Molly Gale

AU - Englund, Elisabet

AU - Kirkeby, Agnete

AU - Jakobsson, Johan

AU - Marklund, Niklas

N1 - Publisher Copyright: © 2023 The Author(s)

PY - 2023

Y1 - 2023

N2 - Traumatic brain injury (TBI) is a leading cause of chronic brain impairment and results in a robust, but poorly understood, neuroinflammatory response that contributes to the long-term pathology. We used single-nuclei RNA sequencing (snRNA-seq) to study transcriptomic changes in different cell populations in human brain tissue obtained acutely after severe, life-threatening TBI. This revealed a unique transcriptional response in oligodendrocyte precursors and mature oligodendrocytes, including the activation of a robust innate immune response, indicating an important role for oligodendroglia in the initiation of neuroinflammation. The activation of an innate immune response correlated with transcriptional upregulation of endogenous retroviruses in oligodendroglia. This observation was causally linked in vitro using human glial progenitors, implicating these ancient viral sequences in human neuroinflammation. In summary, this work provides insight into the initiating events of the neuroinflammatory response in TBI, which has therapeutic implications.

AB - Traumatic brain injury (TBI) is a leading cause of chronic brain impairment and results in a robust, but poorly understood, neuroinflammatory response that contributes to the long-term pathology. We used single-nuclei RNA sequencing (snRNA-seq) to study transcriptomic changes in different cell populations in human brain tissue obtained acutely after severe, life-threatening TBI. This revealed a unique transcriptional response in oligodendrocyte precursors and mature oligodendrocytes, including the activation of a robust innate immune response, indicating an important role for oligodendroglia in the initiation of neuroinflammation. The activation of an innate immune response correlated with transcriptional upregulation of endogenous retroviruses in oligodendroglia. This observation was causally linked in vitro using human glial progenitors, implicating these ancient viral sequences in human neuroinflammation. In summary, this work provides insight into the initiating events of the neuroinflammatory response in TBI, which has therapeutic implications.

KW - CP: Neuroscience

KW - endogenous retroviruses

KW - interferon response

KW - neuroinflammation

KW - oligodendroglia

KW - traumatic brain injury

U2 - 10.1016/j.celrep.2023.113395

DO - 10.1016/j.celrep.2023.113395

M3 - Journal article

C2 - 37967557

AN - SCOPUS:85178228560

VL - 42

JO - Cell Reports

JF - Cell Reports

SN - 2211-1247

IS - 11

M1 - 113395

ER -

ID: 378950303