Modeling human disease using organotypic cultures

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Modeling human disease using organotypic cultures. / Schweiger, Pawel J; Jensen, Kim B.

In: Current Opinion in Cell Biology, Vol. 43, 12.2016, p. 22-29.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Schweiger, PJ & Jensen, KB 2016, 'Modeling human disease using organotypic cultures', Current Opinion in Cell Biology, vol. 43, pp. 22-29. https://doi.org/10.1016/j.ceb.2016.07.003

APA

Schweiger, P. J., & Jensen, K. B. (2016). Modeling human disease using organotypic cultures. Current Opinion in Cell Biology, 43, 22-29. https://doi.org/10.1016/j.ceb.2016.07.003

Vancouver

Schweiger PJ, Jensen KB. Modeling human disease using organotypic cultures. Current Opinion in Cell Biology. 2016 Dec;43:22-29. https://doi.org/10.1016/j.ceb.2016.07.003

Author

Schweiger, Pawel J ; Jensen, Kim B. / Modeling human disease using organotypic cultures. In: Current Opinion in Cell Biology. 2016 ; Vol. 43. pp. 22-29.

Bibtex

@article{7e66b520f4584ab887437c7c7bce8f39,
title = "Modeling human disease using organotypic cultures",
abstract = "Reliable disease models are needed in order to improve quality of healthcare. This includes gaining better understanding of disease mechanisms, developing new therapeutic interventions and personalizing treatment. Up-to-date, the majority of our knowledge about disease states comes from in vivo animal models and in vitro cell culture systems. However, it has been exceedingly difficult to model disease at the tissue level. Since recently, the gap between cell line studies and in vivo modeling has been narrowing thanks to progress in biomaterials and stem cell research. Development of reliable 3D culture systems has enabled a rapid expansion of sophisticated in vitro models. Here we focus on some of the latest advances and future perspectives in 3D organoids for human disease modeling.",
author = "Schweiger, {Pawel J} and Jensen, {Kim B}",
note = "Copyright {\textcopyright} 2016. Published by Elsevier Ltd.",
year = "2016",
month = dec,
doi = "10.1016/j.ceb.2016.07.003",
language = "English",
volume = "43",
pages = "22--29",
journal = "Current Opinion in Cell Biology",
issn = "0955-0674",
publisher = "Elsevier Ltd. * Current Opinion Journals",

}

RIS

TY - JOUR

T1 - Modeling human disease using organotypic cultures

AU - Schweiger, Pawel J

AU - Jensen, Kim B

N1 - Copyright © 2016. Published by Elsevier Ltd.

PY - 2016/12

Y1 - 2016/12

N2 - Reliable disease models are needed in order to improve quality of healthcare. This includes gaining better understanding of disease mechanisms, developing new therapeutic interventions and personalizing treatment. Up-to-date, the majority of our knowledge about disease states comes from in vivo animal models and in vitro cell culture systems. However, it has been exceedingly difficult to model disease at the tissue level. Since recently, the gap between cell line studies and in vivo modeling has been narrowing thanks to progress in biomaterials and stem cell research. Development of reliable 3D culture systems has enabled a rapid expansion of sophisticated in vitro models. Here we focus on some of the latest advances and future perspectives in 3D organoids for human disease modeling.

AB - Reliable disease models are needed in order to improve quality of healthcare. This includes gaining better understanding of disease mechanisms, developing new therapeutic interventions and personalizing treatment. Up-to-date, the majority of our knowledge about disease states comes from in vivo animal models and in vitro cell culture systems. However, it has been exceedingly difficult to model disease at the tissue level. Since recently, the gap between cell line studies and in vivo modeling has been narrowing thanks to progress in biomaterials and stem cell research. Development of reliable 3D culture systems has enabled a rapid expansion of sophisticated in vitro models. Here we focus on some of the latest advances and future perspectives in 3D organoids for human disease modeling.

U2 - 10.1016/j.ceb.2016.07.003

DO - 10.1016/j.ceb.2016.07.003

M3 - Journal article

C2 - 27474805

VL - 43

SP - 22

EP - 29

JO - Current Opinion in Cell Biology

JF - Current Opinion in Cell Biology

SN - 0955-0674

ER -

ID: 165937521