Lrig1 controls intestinal stem-cell homeostasis by negative regulation of ErbB signalling

Research output: Contribution to journal › Journal article › Research

Standard

Lrig1 controls intestinal stem-cell homeostasis by negative regulation of ErbB signalling. / Wong, Vivian W Y; Stange, Daniel E; Page, Mahalia E; Buczacki, Simon; Wabik, Agnieszka; Itami, Satoshi; van de Wetering, Marc; Poulsom, Richard; Wright, Nicholas A; Trotter, Matthew W B; Watt, Fiona M; Winton, Doug J; Clevers, Hans; Jensen, Kim B.

In: Nature Cell Biology, Vol. 14, No. 4, 04.2012, p. 401-8.

Research output: Contribution to journal › Journal article › Research

Harvard

Wong, VWY, Stange, DE, Page, ME, Buczacki, S, Wabik, A, Itami, S, van de Wetering, M, Poulsom, R, Wright, NA, Trotter, MWB, Watt, FM, Winton, DJ, Clevers, H & Jensen, KB 2012, 'Lrig1 controls intestinal stem-cell homeostasis by negative regulation of ErbB signalling', Nature Cell Biology, vol. 14, no. 4, pp. 401-8. https://doi.org/10.1038/ncb2464

APA

Wong, V. W. Y., Stange, D. E., Page, M. E., Buczacki, S., Wabik, A., Itami, S., van de Wetering, M., Poulsom, R., Wright, N. A., Trotter, M. W. B., Watt, F. M., Winton, D. J., Clevers, H., & Jensen, K. B. (2012). Lrig1 controls intestinal stem-cell homeostasis by negative regulation of ErbB signalling. Nature Cell Biology, 14(4), 401-8. https://doi.org/10.1038/ncb2464

Vancouver

Wong VWY, Stange DE, Page ME, Buczacki S, Wabik A, Itami S et al. Lrig1 controls intestinal stem-cell homeostasis by negative regulation of ErbB signalling. Nature Cell Biology. 2012 Apr;14(4):401-8. https://doi.org/10.1038/ncb2464

Author

Wong, Vivian W Y ; Stange, Daniel E ; Page, Mahalia E ; Buczacki, Simon ; Wabik, Agnieszka ; Itami, Satoshi ; van de Wetering, Marc ; Poulsom, Richard ; Wright, Nicholas A ; Trotter, Matthew W B ; Watt, Fiona M ; Winton, Doug J ; Clevers, Hans ; Jensen, Kim B. / Lrig1 controls intestinal stem-cell homeostasis by negative regulation of ErbB signalling. In: Nature Cell Biology. 2012 ; Vol. 14, No. 4. pp. 401-8.

Bibtex

@article{7130bb27e5b040feb6e022856ea07408,
title = "Lrig1 controls intestinal stem-cell homeostasis by negative regulation of ErbB signalling",
abstract = "Maintenance of adult tissues is carried out by stem cells and is sustained throughout life in a highly ordered manner. Homeostasis within the stem-cell compartment is governed by positive- and negative-feedback regulation of instructive extrinsic and intrinsic signals. ErbB signalling is a prerequisite for maintenance of the intestinal epithelium following injury and tumour formation. As ErbB-family ligands and receptors are highly expressed within the stem-cell niche, we hypothesize that strong endogenous regulators must control the pathway in the stem-cell compartment. Here we show that Lrig1, a negative-feedback regulator of the ErbB receptor family, is highly expressed by intestinal stem cells and controls the size of the intestinal stem-cell niche by regulating the amplitude of growth-factor signalling. Intestinal stem-cell maintenance has so far been attributed to a combination of Wnt and Notch activation and Bmpr inhibition. Our findings reveal ErbB activation as a strong inductive signal for stem-cell proliferation. This has implications for our understanding of ErbB signalling in tissue development and maintenance and the progression of malignant disease.",
keywords = "Animals, Feedback, Physiological, Gene Expression Profiling, Genes, erbB, Homeostasis, Intestines, Membrane Glycoproteins, Mice, Mice, Inbred Strains, Mice, Knockout, Nerve Tissue Proteins, Receptor, erbB-2, Signal Transduction, Stem Cell Niche, Stem Cells",
author = "Wong, {Vivian W Y} and Stange, {Daniel E} and Page, {Mahalia E} and Simon Buczacki and Agnieszka Wabik and Satoshi Itami and {van de Wetering}, Marc and Richard Poulsom and Wright, {Nicholas A} and Trotter, {Matthew W B} and Watt, {Fiona M} and Winton, {Doug J} and Hans Clevers and Jensen, {Kim B}",
year = "2012",
month = apr,
doi = "10.1038/ncb2464",
language = "English",
volume = "14",
pages = "401--8",
journal = "Nature Cell Biology",
issn = "1465-7392",
publisher = "nature publishing group",
number = "4",

}

RIS

TY - JOUR

T1 - Lrig1 controls intestinal stem-cell homeostasis by negative regulation of ErbB signalling

AU - Wong, Vivian W Y

AU - Stange, Daniel E

AU - Page, Mahalia E

AU - Buczacki, Simon

AU - Wabik, Agnieszka

AU - Itami, Satoshi

AU - van de Wetering, Marc

AU - Poulsom, Richard

AU - Wright, Nicholas A

AU - Trotter, Matthew W B

AU - Watt, Fiona M

AU - Winton, Doug J

AU - Clevers, Hans

AU - Jensen, Kim B

PY - 2012/4

Y1 - 2012/4

N2 - Maintenance of adult tissues is carried out by stem cells and is sustained throughout life in a highly ordered manner. Homeostasis within the stem-cell compartment is governed by positive- and negative-feedback regulation of instructive extrinsic and intrinsic signals. ErbB signalling is a prerequisite for maintenance of the intestinal epithelium following injury and tumour formation. As ErbB-family ligands and receptors are highly expressed within the stem-cell niche, we hypothesize that strong endogenous regulators must control the pathway in the stem-cell compartment. Here we show that Lrig1, a negative-feedback regulator of the ErbB receptor family, is highly expressed by intestinal stem cells and controls the size of the intestinal stem-cell niche by regulating the amplitude of growth-factor signalling. Intestinal stem-cell maintenance has so far been attributed to a combination of Wnt and Notch activation and Bmpr inhibition. Our findings reveal ErbB activation as a strong inductive signal for stem-cell proliferation. This has implications for our understanding of ErbB signalling in tissue development and maintenance and the progression of malignant disease.

AB - Maintenance of adult tissues is carried out by stem cells and is sustained throughout life in a highly ordered manner. Homeostasis within the stem-cell compartment is governed by positive- and negative-feedback regulation of instructive extrinsic and intrinsic signals. ErbB signalling is a prerequisite for maintenance of the intestinal epithelium following injury and tumour formation. As ErbB-family ligands and receptors are highly expressed within the stem-cell niche, we hypothesize that strong endogenous regulators must control the pathway in the stem-cell compartment. Here we show that Lrig1, a negative-feedback regulator of the ErbB receptor family, is highly expressed by intestinal stem cells and controls the size of the intestinal stem-cell niche by regulating the amplitude of growth-factor signalling. Intestinal stem-cell maintenance has so far been attributed to a combination of Wnt and Notch activation and Bmpr inhibition. Our findings reveal ErbB activation as a strong inductive signal for stem-cell proliferation. This has implications for our understanding of ErbB signalling in tissue development and maintenance and the progression of malignant disease.

KW - Animals

KW - Feedback, Physiological

KW - Gene Expression Profiling

KW - Genes, erbB

KW - Homeostasis

KW - Intestines

KW - Membrane Glycoproteins

KW - Mice

KW - Mice, Inbred Strains

KW - Mice, Knockout

KW - Nerve Tissue Proteins

KW - Receptor, erbB-2

KW - Signal Transduction

KW - Stem Cell Niche

KW - Stem Cells

U2 - 10.1038/ncb2464

DO - 10.1038/ncb2464

M3 - Journal article

C2 - 22388892

VL - 14

SP - 401

EP - 408

JO - Nature Cell Biology

JF - Nature Cell Biology

SN - 1465-7392

IS - 4

ER -

ID: 94414105