Intestinal Organoids: A Tool for Modelling Diet–Microbiome–Host Interactions

Research output: Contribution to journal › Review › Research › peer-review

Standard

Intestinal Organoids : A Tool for Modelling Diet–Microbiome–Host Interactions. / Rubert, Josep; Schweiger, Pawel J.; Mattivi, Fulvio; Tuohy, Kieran; Jensen, Kim B.; Lunardi, Andrea.

In: Trends in Endocrinology and Metabolism, Vol. 31, No. 11, 2020, p. 848-858.

Research output: Contribution to journal › Review › Research › peer-review

Harvard

Rubert, J, Schweiger, PJ, Mattivi, F, Tuohy, K, Jensen, KB & Lunardi, A 2020, 'Intestinal Organoids: A Tool for Modelling Diet–Microbiome–Host Interactions', Trends in Endocrinology and Metabolism, vol. 31, no. 11, pp. 848-858. https://doi.org/10.1016/j.tem.2020.02.004

APA

Rubert, J., Schweiger, P. J., Mattivi, F., Tuohy, K., Jensen, K. B., & Lunardi, A. (2020). Intestinal Organoids: A Tool for Modelling Diet–Microbiome–Host Interactions. Trends in Endocrinology and Metabolism, 31(11), 848-858. https://doi.org/10.1016/j.tem.2020.02.004

Vancouver

Rubert J, Schweiger PJ, Mattivi F, Tuohy K, Jensen KB, Lunardi A. Intestinal Organoids: A Tool for Modelling Diet–Microbiome–Host Interactions. Trends in Endocrinology and Metabolism. 2020;31(11):848-858. https://doi.org/10.1016/j.tem.2020.02.004

Author

Rubert, Josep ; Schweiger, Pawel J. ; Mattivi, Fulvio ; Tuohy, Kieran ; Jensen, Kim B. ; Lunardi, Andrea. / Intestinal Organoids : A Tool for Modelling Diet–Microbiome–Host Interactions. In: Trends in Endocrinology and Metabolism. 2020 ; Vol. 31, No. 11. pp. 848-858.

Bibtex

@article{78a3be41bd7b4925bd05032430211482,
title = "Intestinal Organoids: A Tool for Modelling Diet–Microbiome–Host Interactions",
abstract = "Dietary patterns, microbiome dysbiosis, and gut microbial metabolites (GMMs) have a pivotal role in the homeostasis of intestinal epithelial cells and in disease progression, such as that of colorectal cancer (CRC). Although GMMs and microorganisms have crucial roles in many biological activities, models for deciphering diet–microbiome–host relationships are largely limited to animal models. Thus, intestinal organoids (IOs) have provided unprecedented opportunities for the generation of in vitro platforms with the sufficient level of complexity to model physiological and pathological diet–microbiome–host conditions. Overall, IO responses to GMM metabolites and microorganisms can provide new insights into the mechanisms by which those agents may prevent or trigger diseases, significantly extending our knowledge of diet–microbiome–host interactions.",
keywords = "gut microbial metabolites, intestinal organoids, microbiome, phytochemicals, single cell analysis",
author = "Josep Rubert and Schweiger, {Pawel J.} and Fulvio Mattivi and Kieran Tuohy and Jensen, {Kim B.} and Andrea Lunardi",
year = "2020",
doi = "10.1016/j.tem.2020.02.004",
language = "English",
volume = "31",
pages = "848--858",
journal = "Trends in Endocrinology and Metabolism",
issn = "1043-2760",
publisher = "Elsevier Ltd. * Trends Journals",
number = "11",

}

RIS

TY - JOUR

T1 - Intestinal Organoids

T2 - A Tool for Modelling Diet–Microbiome–Host Interactions

AU - Rubert, Josep

AU - Schweiger, Pawel J.

AU - Mattivi, Fulvio

AU - Tuohy, Kieran

AU - Jensen, Kim B.

AU - Lunardi, Andrea

PY - 2020

Y1 - 2020

N2 - Dietary patterns, microbiome dysbiosis, and gut microbial metabolites (GMMs) have a pivotal role in the homeostasis of intestinal epithelial cells and in disease progression, such as that of colorectal cancer (CRC). Although GMMs and microorganisms have crucial roles in many biological activities, models for deciphering diet–microbiome–host relationships are largely limited to animal models. Thus, intestinal organoids (IOs) have provided unprecedented opportunities for the generation of in vitro platforms with the sufficient level of complexity to model physiological and pathological diet–microbiome–host conditions. Overall, IO responses to GMM metabolites and microorganisms can provide new insights into the mechanisms by which those agents may prevent or trigger diseases, significantly extending our knowledge of diet–microbiome–host interactions.

AB - Dietary patterns, microbiome dysbiosis, and gut microbial metabolites (GMMs) have a pivotal role in the homeostasis of intestinal epithelial cells and in disease progression, such as that of colorectal cancer (CRC). Although GMMs and microorganisms have crucial roles in many biological activities, models for deciphering diet–microbiome–host relationships are largely limited to animal models. Thus, intestinal organoids (IOs) have provided unprecedented opportunities for the generation of in vitro platforms with the sufficient level of complexity to model physiological and pathological diet–microbiome–host conditions. Overall, IO responses to GMM metabolites and microorganisms can provide new insights into the mechanisms by which those agents may prevent or trigger diseases, significantly extending our knowledge of diet–microbiome–host interactions.

KW - gut microbial metabolites

KW - intestinal organoids

KW - microbiome

KW - phytochemicals

KW - single cell analysis

U2 - 10.1016/j.tem.2020.02.004

DO - 10.1016/j.tem.2020.02.004

M3 - Review

C2 - 33086077

AN - SCOPUS:85081277153

VL - 31

SP - 848

EP - 858

JO - Trends in Endocrinology and Metabolism

JF - Trends in Endocrinology and Metabolism

SN - 1043-2760

IS - 11

ER -

ID: 241942710