Immune cell-derived signals governing epithelial phenotypes in homeostasis and inflammation
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Immune cell-derived signals governing epithelial phenotypes in homeostasis and inflammation. / Hausmann, Annika; Steenholdt, Casper; Nielsen, Ole H.; Jensen, Kim B.
In: Trends in Molecular Medicine, Vol. 30, No. 3, 20.03.2024, p. 239-251.Research output: Contribution to journal › Review › Research › peer-review
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TY - JOUR
T1 - Immune cell-derived signals governing epithelial phenotypes in homeostasis and inflammation
AU - Hausmann, Annika
AU - Steenholdt, Casper
AU - Nielsen, Ole H.
AU - Jensen, Kim B.
N1 - Copyright © 2024 The Authors. Published by Elsevier Ltd.. All rights reserved.
PY - 2024/3/20
Y1 - 2024/3/20
N2 - The intestinal epithelium fulfills important physiological functions and forms a physical barrier to the intestinal lumen. Barrier function is regulated by several pathways, and its impairment contributes to the pathogenesis of inflammatory bowel disease (IBD), a chronic inflammatory condition affecting more than seven million people worldwide. Current treatment options specifically target inflammatory mediators and have led to improvement of clinical outcomes; however, a significant proportion of patients experience treatment failure. Pro-repair effects of inflammatory mediators on the epithelium are emerging. In this review we summarize current knowledge on involved epithelial pathways, identify open questions, and put recent findings into clinical perspective, and pro-repair effects. A detailed understanding of epithelial pathways integrating mucosal stimuli in homeostasis and inflammation is crucial for the development of novel, more targeted therapies.
AB - The intestinal epithelium fulfills important physiological functions and forms a physical barrier to the intestinal lumen. Barrier function is regulated by several pathways, and its impairment contributes to the pathogenesis of inflammatory bowel disease (IBD), a chronic inflammatory condition affecting more than seven million people worldwide. Current treatment options specifically target inflammatory mediators and have led to improvement of clinical outcomes; however, a significant proportion of patients experience treatment failure. Pro-repair effects of inflammatory mediators on the epithelium are emerging. In this review we summarize current knowledge on involved epithelial pathways, identify open questions, and put recent findings into clinical perspective, and pro-repair effects. A detailed understanding of epithelial pathways integrating mucosal stimuli in homeostasis and inflammation is crucial for the development of novel, more targeted therapies.
U2 - 10.1016/j.molmed.2024.01.001
DO - 10.1016/j.molmed.2024.01.001
M3 - Review
C2 - 38320941
VL - 30
SP - 239
EP - 251
JO - Trends in Molecular Medicine
JF - Trends in Molecular Medicine
SN - 1471-4914
IS - 3
ER -
ID: 381789356