TY - JOUR

T1 - From Definitive Endoderm to Gut-a Process of Growth and Maturation

AU - Guiu, Jordi

AU - Jensen, Kim B

PY - 2015/9/1

Y1 - 2015/9/1

N2 - The intestine and colon carries out vital functions, and their lifelong maintenance is of the upmost importance. Research over the past decades has carefully addressed bowel function, how it is maintained and begun to unravel how disorders such as cancer and inflammatory bowel disease form. In contrast, very little is known about the molecular mechanisms that trigger tissue maturation during development. With this review, our aim is to carefully provide a critical appraisal of the literature to give a state-of-the-art view of intestinal development. Starting from definitive endoderm at gastrulation to the emergence of a structure with mature properties, the tissue undergoes complex morphogenetic processes that rely on both biophysical changes and secreted signaling molecules. We will also discuss how new and exciting developments using in vitro models are likely to provide new insights into this process and potential therapeutic strategies for gastrointestinal disorders.

AB - The intestine and colon carries out vital functions, and their lifelong maintenance is of the upmost importance. Research over the past decades has carefully addressed bowel function, how it is maintained and begun to unravel how disorders such as cancer and inflammatory bowel disease form. In contrast, very little is known about the molecular mechanisms that trigger tissue maturation during development. With this review, our aim is to carefully provide a critical appraisal of the literature to give a state-of-the-art view of intestinal development. Starting from definitive endoderm at gastrulation to the emergence of a structure with mature properties, the tissue undergoes complex morphogenetic processes that rely on both biophysical changes and secreted signaling molecules. We will also discuss how new and exciting developments using in vitro models are likely to provide new insights into this process and potential therapeutic strategies for gastrointestinal disorders.

KW - Animals

KW - Cell Differentiation

KW - Endoderm

KW - Gastrulation

KW - Humans

KW - Intestines

KW - Mesoderm

KW - Morphogenesis

KW - Journal Article

KW - Research Support, Non-U.S. Gov't

KW - Review

U2 - 10.1089/scd.2015.0017

DO - 10.1089/scd.2015.0017

M3 - Journal article

C2 - 26134088

VL - 24

SP - 1972

EP - 1983

JO - Stem Cells and Development

JF - Stem Cells and Development

SN - 1547-3287

IS - 17

ER -