ERG Controls B Cell Development by Promoting Igh V-to-DJ Recombination
Research output: Contribution to journal › Journal article › Research › peer-review
Documents
- ERG Controls B Cell Development by Promoting Igh V-to-DJ Recombination
Final published version, 5.16 MB, PDF document
Søndergaard et al. demonstrate that ERG is a critical transcriptional regulator essential for B cell development. Loss of ERG leads to a marked reduction in V-to-DJ recombination at the Igh locus, precluding B cell progenitors from expressing the pre-B cell receptor, which is required for entering the final stages of B cell development.
Original language | English |
---|---|
Journal | Cell Reports |
Volume | 29 |
Issue number | 9 |
Pages (from-to) | 2756-2769.e6 |
Number of pages | 21 |
ISSN | 2211-1247 |
DOIs | |
Publication status | Published - 26 Nov 2019 |
- B cell development, ERG, ETS-related gene, immunoglobulin heavy-chain gene, pre-BCR, transcriptional control, V(D)J recombination
Research areas
Number of downloads are based on statistics from Google Scholar and www.ku.dk
No data available
ID: 231505814