Epidermal stem cell diversity and quiescence

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Epidermal stem cell diversity and quiescence. / Watt, Fiona M; Jensen, Kim B.

In: E M B O Molecular Medicine (Online), Vol. 1, No. 5, 08.2009, p. 260-7.

Research output: Contribution to journal › Journal article › Research

Harvard

Watt, FM & Jensen, KB 2009, 'Epidermal stem cell diversity and quiescence', E M B O Molecular Medicine (Online), vol. 1, no. 5, pp. 260-7. https://doi.org/10.1002/emmm.200900033

APA

Watt, F. M., & Jensen, K. B. (2009). Epidermal stem cell diversity and quiescence. E M B O Molecular Medicine (Online), 1(5), 260-7. https://doi.org/10.1002/emmm.200900033

Vancouver

Watt FM, Jensen KB. Epidermal stem cell diversity and quiescence. E M B O Molecular Medicine (Online). 2009 Aug;1(5):260-7. https://doi.org/10.1002/emmm.200900033

Author

Watt, Fiona M ; Jensen, Kim B. / Epidermal stem cell diversity and quiescence. In: E M B O Molecular Medicine (Online). 2009 ; Vol. 1, No. 5. pp. 260-7.

Bibtex

@article{f739e268c73b45d29d6c31493a7057d6,
title = "Epidermal stem cell diversity and quiescence",
abstract = "Mammalian epidermis is maintained by self-renewal of stem cells and terminal differentiation of their progeny. New data reveal a diversity amongst stem cells that was previously unrecognized. Different stem cell populations have different locations and differ in whether they are quiescent or actively cycling. During normal epidermal homeostasis, each stem cell population feeds a restricted number of differentiated lineages. However, in response to injury or genetic manipulation the different pools of stem cells demonstrate multi-lineage differentiation ability. While it is well established that Wnt signalling promotes hair follicle (HF) differentiation, new observations suggest a role for EGF receptor signalling in promoting differentiation of interfollicular epidermis. NFATc1 maintains quiescence in the HF, while Lrig1 exerts the same function in the junctional zone. The stage is now set for exploring the relationship between the different epidermal stem cell populations and between quiescence and lineage selection.",
keywords = "Animals, Cell Differentiation, Cell Lineage, Cell Proliferation, Epidermis, Hair Follicle, Humans, Mice, Signal Transduction, Stem Cells",
author = "Watt, {Fiona M} and Jensen, {Kim B}",
year = "2009",
month = aug,
doi = "10.1002/emmm.200900033",
language = "English",
volume = "1",
pages = "260--7",
journal = "EMBO Molecular Medicine",
issn = "1757-4676",
publisher = "Wiley-Blackwell",
number = "5",

}

RIS

TY - JOUR

T1 - Epidermal stem cell diversity and quiescence

AU - Watt, Fiona M

AU - Jensen, Kim B

PY - 2009/8

Y1 - 2009/8

N2 - Mammalian epidermis is maintained by self-renewal of stem cells and terminal differentiation of their progeny. New data reveal a diversity amongst stem cells that was previously unrecognized. Different stem cell populations have different locations and differ in whether they are quiescent or actively cycling. During normal epidermal homeostasis, each stem cell population feeds a restricted number of differentiated lineages. However, in response to injury or genetic manipulation the different pools of stem cells demonstrate multi-lineage differentiation ability. While it is well established that Wnt signalling promotes hair follicle (HF) differentiation, new observations suggest a role for EGF receptor signalling in promoting differentiation of interfollicular epidermis. NFATc1 maintains quiescence in the HF, while Lrig1 exerts the same function in the junctional zone. The stage is now set for exploring the relationship between the different epidermal stem cell populations and between quiescence and lineage selection.

AB - Mammalian epidermis is maintained by self-renewal of stem cells and terminal differentiation of their progeny. New data reveal a diversity amongst stem cells that was previously unrecognized. Different stem cell populations have different locations and differ in whether they are quiescent or actively cycling. During normal epidermal homeostasis, each stem cell population feeds a restricted number of differentiated lineages. However, in response to injury or genetic manipulation the different pools of stem cells demonstrate multi-lineage differentiation ability. While it is well established that Wnt signalling promotes hair follicle (HF) differentiation, new observations suggest a role for EGF receptor signalling in promoting differentiation of interfollicular epidermis. NFATc1 maintains quiescence in the HF, while Lrig1 exerts the same function in the junctional zone. The stage is now set for exploring the relationship between the different epidermal stem cell populations and between quiescence and lineage selection.

KW - Animals

KW - Cell Differentiation

KW - Cell Lineage

KW - Cell Proliferation

KW - Epidermis

KW - Hair Follicle

KW - Humans

KW - Mice

KW - Signal Transduction

KW - Stem Cells

U2 - 10.1002/emmm.200900033

DO - 10.1002/emmm.200900033

M3 - Journal article

C2 - 20049729

VL - 1

SP - 260

EP - 267

JO - EMBO Molecular Medicine

JF - EMBO Molecular Medicine

SN - 1757-4676

IS - 5

ER -

ID: 94414400