Building authentic midbrain dopaminergic neurons from stem CEllS - Lessons from development
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Building authentic midbrain dopaminergic neurons from stem CEllS - Lessons from development. / Kirkeby, Agnete; Parmar, Malin.
In: Translational Neuroscience, Vol. 3, No. 4, 01.12.2012, p. 314-319.Research output: Contribution to journal › Review › Research › peer-review
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TY - JOUR
T1 - Building authentic midbrain dopaminergic neurons from stem CEllS - Lessons from development
AU - Kirkeby, Agnete
AU - Parmar, Malin
PY - 2012/12/1
Y1 - 2012/12/1
N2 - The challenge with controlling the differentiation of human pluripotent cells to generate functional dopaminergic neurons for the treatment of Parkinson's disease has undergone significant progress in recent years. Here, we summarize the differences between newer and older protocols for generating midbrain dopaminergic neurons from human pluripotent stem cells, and we highlight the importance of following developmental pathways during differentiation. The field has now developed to a point where it is timely to take human pluripotent stem cells one step closer to clinical use, and cell criteria to be fulfilled for such developments are outlined in this review.
AB - The challenge with controlling the differentiation of human pluripotent cells to generate functional dopaminergic neurons for the treatment of Parkinson's disease has undergone significant progress in recent years. Here, we summarize the differences between newer and older protocols for generating midbrain dopaminergic neurons from human pluripotent stem cells, and we highlight the importance of following developmental pathways during differentiation. The field has now developed to a point where it is timely to take human pluripotent stem cells one step closer to clinical use, and cell criteria to be fulfilled for such developments are outlined in this review.
KW - Development
KW - Differentiation
KW - Dopaminergic neurons
KW - Stem cells
UR - http://www.scopus.com/inward/record.url?scp=84871421869&partnerID=8YFLogxK
U2 - 10.2478/s13380-012-0041-x
DO - 10.2478/s13380-012-0041-x
M3 - Review
AN - SCOPUS:84871421869
VL - 3
SP - 314
EP - 319
JO - Translational Neuroscience
JF - Translational Neuroscience
SN - 2081-3856
IS - 4
ER -
ID: 228506253