A stem cell gene expression profile of human squamous cell carcinomas

Research output: Contribution to journal › Journal article › Research

Standard

A stem cell gene expression profile of human squamous cell carcinomas. / Jensen, Kim B; Jones, Judith; Watt, Fiona M.

In: Cancer Letters, Vol. 272, No. 1, 08.12.2008, p. 23-31.

Research output: Contribution to journal › Journal article › Research

Harvard

Jensen, KB, Jones, J & Watt, FM 2008, 'A stem cell gene expression profile of human squamous cell carcinomas', Cancer Letters, vol. 272, no. 1, pp. 23-31. https://doi.org/10.1016/j.canlet.2008.06.014

APA

Jensen, K. B., Jones, J., & Watt, F. M. (2008). A stem cell gene expression profile of human squamous cell carcinomas. Cancer Letters, 272(1), 23-31. https://doi.org/10.1016/j.canlet.2008.06.014

Vancouver

Jensen KB, Jones J, Watt FM. A stem cell gene expression profile of human squamous cell carcinomas. Cancer Letters. 2008 Dec 8;272(1):23-31. https://doi.org/10.1016/j.canlet.2008.06.014

Author

Jensen, Kim B ; Jones, Judith ; Watt, Fiona M. / A stem cell gene expression profile of human squamous cell carcinomas. In: Cancer Letters. 2008 ; Vol. 272, No. 1. pp. 23-31.

Bibtex

@article{c3330accb26a449bb022547475b2a485,
title = "A stem cell gene expression profile of human squamous cell carcinomas",
abstract = "To investigate the relationship between stem cells in normal epithelium and in squamous cell carcinomas (SCCs), we examined expression of a panel of human epidermal stem cell markers in SCCs and SCC cell lines. Markers that are co-expressed in normal stem cells were not co-expressed in SCC. Downregulation of two markers, Lrig1 and MAP4, and upregulation of a third, MCSP, correlated with poor differentiation status and increased proliferation in primary tumours. We conclude that SCCs do not reflect a simple expansion of stem cells; rather, tumour cells hijack the homeostatic controls that operate in normal stem cells, eliminating those that maintain stem cell quiescence.",
keywords = "Adaptor Proteins, Signal Transducing, Carcinoma, Squamous Cell, Cell Differentiation, Cell Division, Cell Line, Tumor, Foreskin, GTP-Binding Proteins, Gene Expression Profiling, Genetic Markers, Humans, Immunohistochemistry, Infant, Newborn, Keratinocytes, Male, Mouth Mucosa, Mouth Neoplasms, Polymerase Chain Reaction, RNA, Messenger, RNA, Neoplasm, Skin, Stem Cells",
author = "Jensen, {Kim B} and Judith Jones and Watt, {Fiona M}",
year = "2008",
month = dec,
day = "8",
doi = "10.1016/j.canlet.2008.06.014",
language = "English",
volume = "272",
pages = "23--31",
journal = "Cancer Letters",
issn = "0304-3835",
publisher = "Elsevier Ireland Ltd",
number = "1",

}

RIS

TY - JOUR

T1 - A stem cell gene expression profile of human squamous cell carcinomas

AU - Jensen, Kim B

AU - Jones, Judith

AU - Watt, Fiona M

PY - 2008/12/8

Y1 - 2008/12/8

N2 - To investigate the relationship between stem cells in normal epithelium and in squamous cell carcinomas (SCCs), we examined expression of a panel of human epidermal stem cell markers in SCCs and SCC cell lines. Markers that are co-expressed in normal stem cells were not co-expressed in SCC. Downregulation of two markers, Lrig1 and MAP4, and upregulation of a third, MCSP, correlated with poor differentiation status and increased proliferation in primary tumours. We conclude that SCCs do not reflect a simple expansion of stem cells; rather, tumour cells hijack the homeostatic controls that operate in normal stem cells, eliminating those that maintain stem cell quiescence.

AB - To investigate the relationship between stem cells in normal epithelium and in squamous cell carcinomas (SCCs), we examined expression of a panel of human epidermal stem cell markers in SCCs and SCC cell lines. Markers that are co-expressed in normal stem cells were not co-expressed in SCC. Downregulation of two markers, Lrig1 and MAP4, and upregulation of a third, MCSP, correlated with poor differentiation status and increased proliferation in primary tumours. We conclude that SCCs do not reflect a simple expansion of stem cells; rather, tumour cells hijack the homeostatic controls that operate in normal stem cells, eliminating those that maintain stem cell quiescence.

KW - Adaptor Proteins, Signal Transducing

KW - Carcinoma, Squamous Cell

KW - Cell Differentiation

KW - Cell Division

KW - Cell Line, Tumor

KW - Foreskin

KW - GTP-Binding Proteins

KW - Gene Expression Profiling

KW - Genetic Markers

KW - Humans

KW - Immunohistochemistry

KW - Infant, Newborn

KW - Keratinocytes

KW - Male

KW - Mouth Mucosa

KW - Mouth Neoplasms

KW - Polymerase Chain Reaction

KW - RNA, Messenger

KW - RNA, Neoplasm

KW - Skin

KW - Stem Cells

U2 - 10.1016/j.canlet.2008.06.014

DO - 10.1016/j.canlet.2008.06.014

M3 - Journal article

C2 - 18657901

VL - 272

SP - 23

EP - 31

JO - Cancer Letters

JF - Cancer Letters

SN - 0304-3835

IS - 1

ER -

ID: 94415277