Philip Allan Seymour
Developmental biology of the pancreas Lab
Blegdamsvej 3B, 2200 København N
Arnes Group
Ole Maaløes Vej 5, 2200 København N
Developmental biology - endoderm and pancreas development Lab
Blegdamsvej 3b, 2200 København N
BasicStem NNF
Blegdamsvej 3b
2200 2200 København N
The Danish Center for Stem Cell Research
Blegdamsvej 3b, Building: 06-4-24
2200 2200 København N
- 2023
- Published
Differential use of the Nkx2.2 NK2 domain in developing pancreatic islets and neurons
Seymour, Philip Allan & Serup, Palle, 2023, In: Genes & Development. 37, 11-12, p. 451-453 3 p.Research output: Contribution to journal › Review › Research › peer-review
- Published
Jag1-Notch cis-interaction determines cell fate segregation in pancreatic development
sgk681, sgk681, Seymour, Philip Allan, Sneppen, Kim, Trusina, Ala, Egeskov-Madsen, A. L. R., Jørgensen, Mette Christine, Jensen, Mogens Høgh & Serup, Palle, 2023, In: Nature Communications. 14, 17 p., 348.Research output: Contribution to journal › Journal article › Research › peer-review
- 2020
- Published
Canonical Notch signaling controls the early thymic epithelial progenitor cell state and emergence of the medullary epithelial lineage in fetal thymus development
Liu, D., Kousa, A. I., O'Neill, K. E., Rouse, P., Popis, M., Farley, A. M., Tomlinson, S. R., Ulyanchenko, Svetlana, Guillemot, F., Seymour, Philip Allan, Jørgensen, Mette Christine, Serup, Palle, Koch, U., Radtke, F. & Blackburn, C. C., 2020, In: Development (Cambridge, England). 147, p. 1-16 dev178582.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Jag1 Modulates an Oscillatory Dll1-Notch-Hes1 Signaling Module to Coordinate Growth and Fate of Pancreatic Progenitors
Seymour, Philip Allan, Collin, C. A., Egeskov-Madsen, A. L. R., Jørgensen, Mette Christine, Shimojo, H., Imayoshi, I., de Lichtenberg, K. H., Kopan, R., Kageyama, R. & Serup, Palle, 2020, In: Developmental Cell. 52, 6, p. 731-747.e8 26 p.Research output: Contribution to journal › Journal article › Research › peer-review
- 2019
- Published
Mesodermal induction of pancreatic fate commitment
Seymour, Philip Allan & Serup, Palle, Aug 2019, In: Seminars in Cell and Developmental Biology. 92, p. 77-88Research output: Contribution to journal › Review › Research › peer-review
- 2018
- Published
Mechanosignalling via integrins directs fate decisions of pancreatic progenitors
Mamidi, A., Prawiro, C., Seymour, Philip Allan, de Lichtenberg, K. H., Jackson, Abigail Laura, Serup, Palle & Semb, Tor Henrik, Dec 2018, In: Nature. 564, 7734, p. 114-118 5 p.Research output: Contribution to journal › Letter › Research › peer-review
- Published
Inhibition of Cdk5 Promotes β-Cell Differentiation From Ductal Progenitors
Liu, K., Leuckx, G., Sakano, D., Seymour, Philip Allan, Mattsson, C. L., Rautio, L., Staels, W., Verdonck, Y., Serup, Palle, Kume, S., Heimberg, H. & Andersson, O., Jan 2018, In: Diabetes. 67, 1, p. 58-70 13 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Notch Controls Multiple Pancreatic Cell Fate Regulators Through Direct Hes1-mediated Repression
de Lichtenberg, K. H., Seymour, Philip Allan, Jørgensen, Mette Christine, Kim, Y., Grapin-Botton, A., Magnuson, M. A., Nakic, N., Ferrer, J. & Serup, Palle, 2018, bioRxiv, 30 p. (bioRxiv, Developmental Biology).Research output: Working paper › Preprint › Research
- 2016
- Published
Research Resource: A Dual Proteomic Approach Identifies Regulated Islet Proteins During β-Cell Mass Expansion In Vivo
Horn, S., Kirkegaard, J. S., Hoelper, S., Seymour, Philip Allan, Rescan, C., Nielsen, Jens Høiriis, Madsen, O. D., Jensen, J. N., Kruger, M., Gronborg, M. & Ahnfelt-Rønne, J., 2016, In: Molecular endocrinology (Baltimore, Md.). 30, 1, p. 133-143 11 p.Research output: Contribution to journal › Journal article › Research › peer-review
- 2015
- Published
A Gene Regulatory Network Cooperatively Controlled by Pdx1 and Sox9 Governs Lineage Allocation of Foregut Progenitor Cells
Shih, H. P., Seymour, Philip Allan, Patel, N. A., Xie, R., Wang, A., Liu, P. P., Yeo, G. W., Magnuson, M. A. & Sander, M., 13 Oct 2015, In: Cell Reports. 13, 2, p. 326-36 11 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Pairing-up SOX to kick-start beta cell genesis
Grapin-Botton, A., Seymour, Philip Allan & Gradwohl, G., May 2015, In: Diabetologia. 58, 5, p. 859-861 3 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
A conserved role for Notch in priming the cellular response to Shh through ciliary localisation of the key Shh transducer, Smoothened
Stasiulewicz, M., Gray, S., Mastromina, I., Silva, J. C., Bjorklund, M., Seymour, Philip Allan, Booth, D., Thompson, C., Green, R., Hall, E. A., Serup, Palle & Dale, J. K., 2015, In: Development. 142, p. 2291-2303 13 p.Research output: Contribution to journal › Journal article › Research › peer-review
- 2014
- Published
Sox9: a master regulator of the pancreatic program
Seymour, Philip Allan, 2014, In: The Review of Diabetic Studies. 11, 1, p. 51-83 33 p.Research output: Contribution to journal › Review › Research › peer-review
- 2013
- Published
Bulking up on beta cells
Seymour, Philip Allan & Serup, Palle, 22 Aug 2013, In: Briefings from the New England Journal of Medicine (Spanish Edition). 369, 8, p. 777-9 3 p.Research output: Contribution to journal › Review › Research › peer-review
- 2012
A Sox9/Fgf feed-forward loop maintains pancreatic organ identity
Seymour, Philip Allan, Shih, H. P., Patel, N. A., Freude, Kristine, Xie, R., Lim, C. J. & Sander, M., Sep 2012, In: Development. 139, 18, p. 3363-72 10 p.Research output: Contribution to journal › Journal article › Research › peer-review
- 2011
Historical perspective: beginnings of the beta-cell: current perspectives in beta-cell development
Seymour, Philip Allan & Sander, M., Feb 2011, In: Diabetes. 60, 2, p. 364-76 13 p.Research output: Contribution to journal › Journal article › Research › peer-review
Sox9+ ductal cells are multipotent progenitors throughout development but do not produce new endocrine cells in the normal or injured adult pancreas
Kopp, J. L., Dubois, C. L., Schaffer, A. E., Hao, E., Shih, H. P., Seymour, Philip Allan, Ma, J. & Sander, M., Feb 2011, In: Development. 138, 4, p. 653-65 13 p.Research output: Contribution to journal › Journal article › Research › peer-review
Sox9-haploinsufficiency causes glucose intolerance in mice
Dubois, C. L., Shih, H. P., Seymour, Philip Allan, Patel, N. A., Behrmann, J. M., Ngo, V. & Sander, M., 2011, In: P L o S One. 6, 8, p. e23131Research output: Contribution to journal › Journal article › Research › peer-review
- 2009
Sustained Neurog3 expression in hormone-expressing islet cells is required for endocrine maturation and function
Wang, S., Jensen, J. N., Seymour, Philip Allan, Hsu, W., Dor, Y., Sander, M., Magnuson, M. A., Serup, P. & Gu, G., 16 Jun 2009, In: PNAS Early Edition. 106, 24, p. 9715-20 6 p.Research output: Contribution to journal › Journal article › Research › peer-review
- 2008
A dosage-dependent requirement for Sox9 in pancreatic endocrine cell formation
Seymour, Philip Allan, Freude, Kristine, Dubois, C. L., Shih, H., Patel, N. A. & Sander, M., 1 Nov 2008, In: Advances in Developmental Biology. 323, 1, p. 19-30 12 p.Research output: Contribution to journal › Journal article › Research › peer-review
- 2007
SOX9 is required for maintenance of the pancreatic progenitor cell pool
Seymour, Philip Allan, Freude, Kristine, Tran, M. N., Mayes, E. E., Jensen, J., Kist, R., Scherer, G. & Sander, M., 6 Feb 2007, In: Proceedings of the National Academy of Sciences of the United States of America. 104, 6, p. 1865-70 6 p.Research output: Contribution to journal › Journal article › Research › peer-review
Immunohistochemical detection of beta-galactosidase or green fluorescent protein on tissue sections
Seymour, Philip Allan & Sander, M., 2007, In: Methods in Molecular Biology. 411, p. 13-23 11 p.Research output: Contribution to journal › Journal article › Research › peer-review
- 2004
Pancreatic islet progenitor cells in neurogenin 3-yellow fluorescent protein knock-add-on mice
Mellitzer, G., Martín, M., Sidhoum-Jenny, M., Orvain, C., Barths, J., Seymour, Philip Allan, Sander, M. & Gradwohl, G., Nov 2004, In: Molecular Endocrinology. 18, 11, p. 2765-76 12 p.Research output: Contribution to journal › Journal article › Research › peer-review
Fission of pancreatic islets during postnatal growth of the mouse
Seymour, Philip Allan, Bennett, W. R. & Slack, J. M. W., Feb 2004, In: Journal of Anatomy. 204, 2, p. 103-16 14 p.Research output: Contribution to journal › Journal article › Research › peer-review
ID: 40446254
Most downloads
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Jag1-Notch cis-interaction determines cell fate segregation in pancreatic development
Research output: Contribution to journal › Journal article › Research › peer-review
Published -
22
downloads
Canonical Notch signaling controls the early thymic epithelial progenitor cell state and emergence of the medullary epithelial lineage in fetal thymus development
Research output: Contribution to journal › Journal article › Research › peer-review
Published