Agnete Kirkeby

Agnete Kirkeby

Guest Researcher, Associate professor, group leader


  1. 2023
  2. Published

    Characterising the RNA-binding protein atlas of the mammalian brain uncovers RBM5 misregulation in mouse models of Huntington's disease

    Mullari, M., Fossat, Nicolas Julien, Skotte, Niels Henning, Asenjo-Martinez, A., Humphreys, D. T., Bukh, Jens, Kirkeby, Agnete, Scheel, Troels Kasper Høyer & Nielsen, Michael Lund, 2023, In: Nature Communications. 14, 20 p., 4348.

    Research output: Contribution to journalJournal articlepeer-review

  3. Published

    Identifying secreted biomarkers of dopaminergic ventral midbrain progenitor cells

    Rifes, P., Isaksson, M., Rusimbi, Charlotte Nuru, Ramón Santonja, A., Nelander, J., Laurell, T. & Kirkeby, Agnete, 2023, In: Stem Cell Research and Therapy. 14, 1, 354.

    Research output: Contribution to journalJournal articlepeer-review

  4. Published

    Preclinical quality, safety, and efficacy of a human embryonic stem cell-derived product for the treatment of Parkinson's disease, STEM-PD

    Novo Nordisk Cell Therapy R&D, N. N. C. T. R., 2023, In: Cell Stem Cell. 30, 10, p. 1299-1314.e9 17 p.

    Research output: Contribution to journalJournal articlepeer-review

  5. Published
  6. Published

    Single-cell transcriptomics of human traumatic brain injury reveals activation of endogenous retroviruses in oligodendroglia

    Garza, R., Sharma, Y., Atacho, D. A. M., Thiruvalluvan, Arun, Abu Hamdeh, S., Jönsson, M. E., Horvath, V., Adami, A., Ingelsson, M., Jern, P., Hammell, M. G., Englund, E., Kirkeby, Agnete, Jakobsson, J. & Marklund, N., 2023, In: Cell Reports. 42, 11, 19 p., 113395.

    Research output: Contribution to journalJournal articlepeer-review

  7. 2022
  8. Published

    Current advancements of modelling schizophrenia using patient-derived induced pluripotent stem cells

    Dubonyte, Ugne, Asenjo-Martinez, A., Werge, Thomas, Lage, K. & Kirkeby, Agnete, 2022, In: Acta Neuropathologica Communications. 10, 1, 20 p., 183.

    Research output: Contribution to journalReviewpeer-review

  9. Published

    Human Embryonic Stem Cell-Derived Dopaminergic Grafts Alleviate L-DOPA Induced Dyskinesia

    Elabi, O. F., Pass, R., Sormonta, I., Nolbrant, S., Drummond, N., Kirkeby, Agnete, Kunath, T., Parmar, M. & Lane, E. L., 2022, In: Journal of Parkinson's Disease. 12, 6, p. 1881-1896 16 p.

    Research output: Contribution to journalJournal articlepeer-review

  10. Published

    MSLibrarian: Optimized Predicted Spectral Libraries for Data-Independent Acquisition Proteomics

    Isaksson, M., Karlsson, C., Laurell, T., Kirkeby, Agnete & Heusel, M., 2022, In: Journal of Proteome Research. 21, 2, p. 535–546 12 p.

    Research output: Contribution to journalJournal articlepeer-review

  11. 2021
  12. Published

    Bringing Advanced Therapies for Parkinson's Disease to the Clinic: The Scientist's Perspective

    Tomishima, M. & Kirkeby, Agnete, 2021, In: Journal of Parkinson's Disease. 11, p. S135-S140 6 p.

    Research output: Contribution to journalReviewpeer-review

  13. Published

    Preclinical assessment of a pluripotent cell therapy for treatment of Parkinson's Disease

    Kirkeby, Agnete, 2021, In: Toxicology Letters. 350, Supplement, p. S37 1 p.

    Research output: Contribution to journalConference abstract in journalpeer-review

  14. 2020
  15. Published

    Single cell transcriptomics identifies stem cell-derived graft composition in a model of Parkinson’s disease

    Tiklová, K., Nolbrant, S., Fiorenzano, A., Björklund, Å. K., Sharma, Y., Heuer, A., Gillberg, L., Hoban, D. B., Cardoso, T., Adler, A. F., Birtele, M., Lundén-Miguel, H., Volakakis, N., Kirkeby, Agnete, Perlmann, T. & Parmar, M., 1 Dec 2020, In: Nature Communications. 11, 1, 11 p., 2434.

    Research output: Contribution to journalJournal articlepeer-review

  16. Published

    Genetic modification increases the survival and the neuroregenerative properties of transplanted neural stem cells

    Korshunova, Irina, Rhein, S., vsz834, vsz834, Stölting, I., Pfisterer, U., Barta, A., Dmytriyeva, O., Kirkeby, Agnete, Schwaninger, M. & Khodosevich, Konstantin, 2020, In: JCI insight. 5, 4, p. 1-19 e126268.

    Research output: Contribution to journalJournal articlepeer-review

  17. Published

    Modeling neural tube development by differentiation of human embryonic stem cells in a microfluidic WNT gradient

    Rifes, P., Isaksson, M., Rathore, Gaurav Singh, Aldrin-Kirk, P., Moller, O. K., Barzaghi, G., Lee, J., Egerod, Kristoffer Lihme, Belmont-Rausch, Dylan Matthew, Parmar, M., Pers, Tune H, Laurell, T. & Kirkeby, Agnete, 2020, In: Nature Biotechnology. 38, p. 1265-1273 9 p.

    Research output: Contribution to journalLetterpeer-review

  18. 2019
  19. Published

    Parkinson disease and growth factors — is GDNF good enough?

    Kirkeby, Agnete & Barker, R. A., 1 Jun 2019, In: Nature Reviews Neurology. 15, 6, p. 312-314 3 p.

    Research output: Contribution to journalComment/debatepeer-review

  20. 2018
  21. Published

    Report of the international conference on manufacturing and testing of pluripotent stem cells

    Abbot, S., Agbanyo, F., Ahlfors, J-E., Baghbaderani, B. A., Bartido, S., Bharti, K., Burke, C., Carlsson, B., Cavagnaro, J., Creasey, A., Lin, S., DiGiusto, D., Francissen, K., Gaffney, A., Goldring, C., Gorba, T., Griffiths, E., Lubiniecki, A., Vandeputte, J., Hanatani, T. & 23 others, Hayakawa, T., Heki, T., Hoogendoorn, K., Kawamata, S., Kimura, H., Kirkeby, Agnete, Knezevic, I., Lebkowski, J., Lin-Gibson, S., O'Shea, O., Pera, M., Petricciani, J., Pigeau, G., Ratcliffe, A., Sato, Y., Schumann, G. G., Shingleton, W., Stacey, C. G., Sullivan, S., Svendsen, C. N., Trouvin, J., Yuan, B. & Zoon, K., Nov 2018, In: Biologicals. 63, p. 67-83

    Research output: Contribution to journalConference articlepeer-review

  22. Published

    Target-specific forebrain projections and appropriate synaptic inputs of hESC-derived dopamine neurons grafted to the midbrain of parkinsonian rats

    Cardoso, T., Adler, A. F., Mattsson, B., Hoban, D. B., Nolbrant, S., Wahlestedt, J. N., Kirkeby, Agnete, Grealish, S., Björklund, A. & Parmar, M., 1 Sep 2018, In: The Journal of Comparative Neurology. 526, 13, p. 2133-2146

    Research output: Contribution to journalJournal articlepeer-review

  23. Published

    A symphony of stem cells in Vienna - looking to the future

    Porrello, E. R. & Kirkeby, Agnete, 8 Jun 2018, In: Development (Cambridge, England). 145, 11, 6 p., 163501.

    Research output: Contribution to journalConference articlepeer-review

  24. Published

    Sense-Antisense lncRNA Pair Encoded by Locus 6p22.3 Determines Neuroblastoma Susceptibility via the USP36-CHD7-SOX9 Regulatory Axis

    Mondal, T., Juvvuna, P. K., Kirkeby, A., Mitra, S., Kosalai, S. T., Traxler, L., Hertwig, F., Wernig-Zorc, S., Miranda, C., Deland, L., Volland, R., Bartenhagen, C., Bartsch, D., Bandaru, S., Engesser, A., Subhash, S., Martinsson, T., Carén, H., Akyürek, L. M., Kurian, L. & 5 others, Kanduri, M., Huarte, M., Kogner, P., Fischer, M. & Kanduri, C., 12 Mar 2018, In: Cancer Cell. 33, 3, p. 417-434.e7

    Research output: Contribution to journalJournal articlepeer-review

  25. 2017
  26. Published

    IAP-Based Cell Sorting Results in Homogeneous Transplantable Dopaminergic Precursor Cells Derived from Human Pluripotent Stem Cells.

    Lehnen, D., Barral, S., Cardoso, T., Grealish, S., Heuer, A., Smiyakin, A., Kirkeby, Agnete, Kollet, J., Cremer, H., Parmar, M., Bosio, A. & Knoebel, S., Oct 2017, In: Stem Cell Reports. 9, 4, p. 1207-1220 14 p.

    Research output: Contribution to journalJournal articlepeer-review

  27. Term amniotic fluid: an unexploited reserve of mesenchymal stromal cells for reprogramming and potential cell therapy applications.

    Moraghebi, R., Kirkeby, Agnete, Chaves, P., Roenn, R. E., Sitnicka, E., Parmar, M., Larsson, M., Herbst, A. & Woods, N., 25 Aug 2017, In: Stem Cell Research & Therapy. 8, 12 p., 190.

    Research output: Contribution to journalJournal articlepeer-review

  28. Published

    Single-Cell Analysis Reveals a Close Relationship between Differentiating Dopamine and Subthalamic Nucleus Neuronal Lineages.

    Kee, N., Volakakis, N., Kirkeby, Agnete, Dahl, L., Storvall, H., Nolbrant, S., Lahti, L., Bjoerklund, A. K., Gillberg, L., Joodmardi, E., Sandberg, R., Parmar, M. & Perlmann, T., 5 Jan 2017, In: Cell Stem Cell. 20, 1, p. 29-40 12 p.

    Research output: Contribution to journalJournal articlepeer-review

  29. Published
  30. Published

    Generation of high-purity human ventral midbrain dopaminergic progenitors for in vitro maturation and intracerebral transplantation

    Nolbrant, S., Heuer, A., Parmar, M. & Kirkeby, Agnete, 2017, In: Nature Protocols. 12, 9, p. 1962-1979

    Research output: Contribution to journalJournal articlepeer-review

  31. Predictive Markers Guide Differentiation to Improve Graft Outcome in Clinical Translation of hESC-Based Therapy for Parkinson's Disease.

    Kirkeby, Agnete, Nolbrant, S., Tiklova, K., Heuer, A., Kee, N., Cardoso, T., Ottosson, D. R., Lelos, M. J., Rifes, P., Dunnett, S. B., Grealish, S., Perlmann, T. & Parmar, M., 2017, In: Cell Stem Cell. 20, 1, p. 135-148 14 p.

    Research output: Contribution to journalJournal articlepeer-review

  32. Strategies for bringing stem cell-derived dopamine neurons to the clinic: A European approach (STEM-PD)

    Kirkeby, Agnete, Parmar, M. & Barker, R. A., 2017, Functional Neural Transplantation IV: Translation to Clinical Application, Part A. Vol. 230. p. 165-190 26 p. (Progress in Brain Research).

    Research output: Chapter in Book/Report/Conference proceedingBook chapterResearchpeer-review

  33. 2016
  34. Published

    The stem cell niche finds its true north

    Kirkeby, Agnete, Perlmann, T. & Pereira, C. F., 15 Aug 2016, In: Development (Cambridge). 143, 16, p. 2877-2881 5 p.

    Research output: Contribution to journalReviewpeer-review

  35. HESC-derived neural progenitors prevent xenograft rejection through neonatal desensitisation

    Heuer, A., Jönsson, M. E., Pfisterer, U., Kirkeby, Agnete & Parmar, M., 1 Aug 2016, In: Experimental Neurology. 282, p. 78-85 8 p.

    Research output: Contribution to journalJournal articlepeer-review

  36. Are Stem Cell-Based Therapies for Parkinson's Disease Ready for the Clinic in 2016?

    Barker, R. A., Parmar, M., Kirkeby, Agnete, Björklund, A., Thompson, L. & Brundin, P., 30 Mar 2016, In: Journal of Parkinson's Disease. 6, 1, p. 57-63 7 p.

    Research output: Contribution to journalReviewpeer-review

  37. 2015
  38. Published

    Comprehensive analysis of microrna expression in regionalized human neural progenitor cells reveals microRNA-10 as a caudalizing factor

    Jönsson, M. E., Wahlestedt, J. N., Åkerblom, M., Kirkeby, Agnete, Malmevik, J., Brattaas, P. L., Jakobsson, J. & Parmar, M., 23 Sep 2015, In: Development (Cambridge). 142, 18, p. 3166-3177 12 p.

    Research output: Contribution to journalJournal articlepeer-review

  39. Published

    Monosynaptic Tracing using Modified Rabies Virus Reveals Early and Extensive Circuit Integration of Human Embryonic Stem Cell-Derived Neurons

    Grealish, S., Heuer, A., Cardoso, T., Kirkeby, Agnete, Jönsson, M., Johansson, J., Björklund, A., Jakobsson, J. & Parmar, M., 9 Jun 2015, In: Stem Cell Reports. 4, 6, p. 975-983 9 p.

    Research output: Contribution to journalJournal articlepeer-review

  40. 2014
  41. Published

    Human ESC-derived dopamine neurons show similar preclinical efficacy and potency to fetal neurons when grafted in a rat model of Parkinson's disease

    Grealish, S., Diguet, E., Kirkeby, Agnete, Mattsson, B., Heuer, A., Bramoulle, Y., Van Camp, N., Perrier, A. L., Hantraye, P., Björklund, A. & Parmar, M., 1 Jan 2014, In: Cell Stem Cell. 15, 5, p. 653-665 13 p.

    Research output: Contribution to journalJournal articlepeer-review

  42. 2013
  43. Published

    Generating regionalized neuronal cells from pluripotency, a step-by-stepprotocol

    Kirkeby, Agnete, Nelander, J. & Parmar, M., 3 Jan 2013, In: Frontiers in Cellular Neuroscience. JANUARY 2013

    Research output: Contribution to journalJournal articlepeer-review

  44. 2012
  45. Published

    Building authentic midbrain dopaminergic neurons from stem CEllS - Lessons from development

    Kirkeby, Agnete & Parmar, M., 1 Dec 2012, In: Translational Neuroscience. 3, 4, p. 314-319 6 p.

    Research output: Contribution to journalReviewpeer-review

  46. Published

    Generation of Regionally Specified Neural Progenitors and Functional Neurons from Human Embryonic Stem Cells under Defined Conditions

    Kirkeby, Agnete, Grealish, S., Wolf, D. A., Nelander, J., Wood, J., Lundblad, M., Lindvall, O. & Parmar, M., 28 Jun 2012, In: Cell Reports. 1, 6, p. 703-714 12 p.

    Research output: Contribution to journalJournal articlepeer-review

  47. 2011
  48. Published

    Direct conversion of human fibroblasts to dopaminergic neurons

    Pfisterer, U., Kirkeby, Agnete, Torper, O., Wood, J., Nelander, J., Dufour, A., Björklund, A., Lindvall, O., Jakobsson, J. & Parmar, M., 21 Jun 2011, In: Proceedings of the National Academy of Sciences of the United States of America. 108, 25, p. 10343-10348 6 p.

    Research output: Contribution to journalJournal articlepeer-review

  49. 2010
  50. Published

    Tracking differentiating neural progenitors in pluripotent cultures using microRNA-regulated lentiviral vectors

    Sachdeva, R., Jönsson, M. E., Nelander, J., Kirkeby, Agnete, Guibentif, C., Gentner, B., Naldini, L., Björklund, A., Parmar, M. & Jakobsson, J., 22 Jun 2010, In: Proceedings of the National Academy of Sciences of the United States of America. 107, 25, p. 11602-11607 6 p.

    Research output: Contribution to journalJournal articlepeer-review

  51. 2008
  52. Published

    The biological and ethical basis of the use of human embryonic stem cells for in vitro test systems or cell therapy

    Leist, M., Bremer, S., Brundin, P., Hescheler, J., Kirkeby, Agnete, Krause, K. H., Pörzgen, P., Pucéat, M., Schmidt, M., Schrattenholz, A., Zak, N. B. & Hentze, H., 1 Dec 2008, In: Altex. 25, 3, p. 163-190 28 p.

    Research output: Contribution to journalReviewpeer-review

  53. Published

    Therapeutic window for nonerythropoietic carbamylated-erythropoietin to improve motor function following multiple infarct ischemic strokes in New Zealand white rabbits

    Lapchak, P. A., Kirkeby, Agnete, Zivin, J. A. & Sager, T. N., 31 Oct 2008, In: Brain Research. 1238, p. 208-214 7 p.

    Research output: Contribution to journalJournal articlepeer-review

  54. Published

    High-dose erythropoietin alters platelet reactivity and bleeding time in rodents in contrast to the neuroprotective variant carbamyl-erythropoietin (CEPO).

    Kirkeby, Agnete, Torup, L., Bochsen, L., Kjalke, M., Abel, K., Theilgaard-Mønch, Kim, Johansson, P. I., Bjørn, S. E., Gerwien, J. & Leist, M., 2008, In: Thrombosis and Haemostasis. 99, 4, p. 720-8 8 p.

    Research output: Contribution to journalJournal articlepeer-review

  55. 2007
  56. Published

    Functional and immunochemical characterisation of different antibodies against the erythropoietin receptor

    Kirkeby, Agnete, van Beek, J., Nielsen, J., Leist, M. & Helboe, L., 15 Aug 2007, In: Journal of Neuroscience Methods. 164, 1, p. 50-58 9 p.

    Research output: Contribution to journalJournal articlepeer-review

  57. Published

    Comparison of neuroprotective effects of erythropoietin (EPO) and carbamylerythropoietin (CEPO) against ischemia-like oxygen-glucose deprivation (OGD) and NMDA excitotoxicity in mouse hippocampal slice cultures

    Montero, M., Poulsen, F. R., Noraberg, J., Kirkeby, Agnete, van Beek, J., Leist, M. & Zimmer, J., 1 Mar 2007, In: Experimental Neurology. 204, 1, p. 106-117 12 p.

    Research output: Contribution to journalJournal articlepeer-review

ID: 172979835